GDC-0879

目录号: A10420

B-Raf 抑制剂

GDC-0879

GDC-0879 Chemical Structure

CAS NO. 905281-76-7

GDC-0879是B-Raf激酶的特异性抑制剂,靶向B-Raf (V600E) (IC50: 0.13 nM)。

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,600.00
25 mg
¥ 3,000.00
50 mg
¥ 5,200.00
10mM * 1mL in DMSO
¥ 1,190.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GDC-0879是B-Raf激酶的特异性抑制剂,靶向B-Raf (V600E) (IC50: 0.13 nM)。
靶点信息
B-Raf (A375, Colo205 cells)
0.13 nM
In vitro (25°C) DMSO Warmed: 65 mg/mL (194.39 mM)
Water Insoluble
Ethanol 5 mg/mL (14.95 mM)
In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.9 mL 149.52 mL 299.04 mL
0.5 mM 5.98 mL 29.9 mL 59.81 mL
1 mM 2.99 mL 14.95 mL 29.9 mL
5 mM 0.6 mL 2.99 mL 5.98 mL

*The above data is based on the productmolecular weight 334.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10420
作用机制 Inhibitor (抑制剂)
M. Wt 334.4
Formula C19H18N4O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 905281-76-7
Synonyms GDC0879
SMILES C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

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