GDC-0973 (Cobimetinib)

目录号: A11441

MEK1 抑制剂

GDC-0973 (Cobimetinib)

GDC-0973 (Cobimetinib) Chemical Structure

CAS NO. 934660-93-2

GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂,IC50为4.2 nM,对MEK1的选择性选择性是对MEK2的100倍以上,并且当针对一组超过100个丝氨酸的抑制剂进行测试时,没有显示出明显的抑制作用。

库存: 现货

规格 价格 数量
5 mg
¥ 850.00
10 mg
¥ 1,100.00
25 mg
¥ 2,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂,IC50为4.2 nM,对MEK1的选择性选择性是对MEK2的100倍以上,并且当针对一组超过100个丝氨酸的抑制剂进行测试时,没有显示出明显的抑制作用。
靶点信息
MEK1
4.2 nM
In vitro (25°C) DMSO 88 mg/mL (165.62 mM)
Water Insoluble
Ethanol Warmed: 41 mg/mL (77.17 mM)
In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.86 mL 94.32 mL 188.64 mL
0.5 mM 3.77 mL 18.86 mL 37.73 mL
1 mM 1.89 mL 9.43 mL 18.86 mL
5 mM 0.38 mL 1.89 mL 3.77 mL

*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11441
作用机制 Inhibitor (抑制剂)
M. Wt 530.1
Formula C21H21F3IN3O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 934660-93-2
Synonyms XL518, XL 518, XL-518, RG7420
SMILES C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O

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