GDC-0980 (Apitolisib, RG7422)

目录号: A11023

mTOR/PI3K 抑制剂

GDC-0980 (Apitolisib, RG7422)

GDC-0980 (Apitolisib, RG7422) Chemical Structure

CAS NO. 1032754-93-0

GDC-0980 (Apitolisib,RG7422)是一种有效的,I型PI3激酶和mTOR激酶抑制剂(TORC1/2),对于p110α,β,δ和γ的体外IC50为5、27、7和14 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 2,600.00
100 mg
¥ 4,400.00
10mM * 1mL in DMSO
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GDC-0980 (Apitolisib,RG7422)是一种有效的,I型PI3激酶和mTOR激酶抑制剂(TORC1/2),对于p110α,β,δ和γ的体外IC50为5、27、7和14 nM。
靶点信息
p110α (Cell-free assay) p110δ (Cell-free assay) p110γ (Cell-free assay) mTOR (Cell-free assay) p110β (Cell-free assay)
5 nM7 nM14 nM17 nM(Ki app)27 nM
In vitro (25°C) DMSO 20 mg/mL (40.11 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.06 mL 100.28 mL 200.56 mL
0.5 mM 4.01 mL 20.06 mL 40.11 mL
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11023
作用机制 Inhibitor (抑制剂)
M. Wt 498.6
Formula C23H30N8O3S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1032754-93-0
Synonyms GDC0980
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O

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