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Gefitinib hydrochloride是一种EGFR抑制剂，可通过靶细胞中的表皮生长因子受体（EGFR）中断信号传导。因此，它仅在EGFR突变和过度活跃的癌症中有效。
| In vitro | DMSO | 7 mg/mL (14.48 mM) | |
| Water | 1 mg/mL (2.06 mM) | ||
| Ethanol | 1 mg/mL (2.06 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.69 mL | 103.44 mL | 206.89 mL |
| 0.5 mM | 4.14 mL | 20.69 mL | 41.38 mL |
| 1 mM | 2.07 mL | 10.34 mL | 20.69 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
*The above data is based on the productmolecular weight 483.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15093 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 483.36 |
| Formula | C22H25Cl2FN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 184475-55-6 |
| Synonyms | Iressa hydrochloride, ZD 1839 hydrochloride, ZD-1839 hydrochloride, ZD1839 hydrochloride |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl |
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