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GNE-477是一种有效的PI3K/mTOR双重抑制剂，PI3Kα的IC50为4 nM，Kiapp为mTOR的IC50为21 nM。
| In vitro | DMSO | 24 mg/mL (47.56 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.82 mL | 99.08 mL | 198.16 mL |
| 0.5 mM | 3.96 mL | 19.82 mL | 39.63 mL |
| 1 mM | 1.98 mL | 9.91 mL | 19.82 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
*The above data is based on the productmolecular weight 504.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14114 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 504.64 |
| Formula | C21H28N8O3S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1032754-81-6 |
| Synonyms | GNE-477,GNE477 |
| SMILES | CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C |
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