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GO6983是有效的蛋白激酶C（PKC）抑制剂。它减少了心肌缺血/再灌注损伤后多形核白细胞的粘附和浸润。
Targets
| Target | Value |
|---|---|
| PKCγ | IC50: 6nM |
| PKCα | IC50: 7nM |
| PKCβ | IC50: 7nM |
| PKCδ | IC50: 10nM |
| PKCζ | IC50: 60nM |
| PKCμ | IC50: 20μM |
| In vitro (25°C) | DMSO | 55 mg/mL (124.29 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.6 mL | 112.99 mL | 225.98 mL |
| 0.5 mM | 4.52 mL | 22.6 mL | 45.2 mL |
| 1 mM | 2.26 mL | 11.3 mL | 22.6 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13790 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 442.51 |
| Formula | C26H26N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 133053-19-7 |
| Synonyms | Go-6983, Go 6983 |
| SMILES | CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 |
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