GSK 1210151A (I-BET151)

Name: GSK 1210151A (I-BET151)
SKU: A11783

目录号: A11783

BET Bromodomain 抑制剂

Product Citations (1)

GSK 1210151A (I-BET151) Chemical Structure

CAS NO. 1300031-49-5

GSK 1210151A (I-BET151)是溴结构域和额外末端（BET）家族蛋白BRD2，BRD3和BRD4的新型选择性抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 800.00
10 mg	￥ 1,200.00
25 mg	￥ 2,000.00
50 mg	￥ 3,600.00

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生物活性

GSK 1210151A (I-BET151)是溴结构域和额外末端（BET）家族蛋白BRD2，BRD3和BRD4的新型选择性抑制剂。

靶点信息

BRD3 (Cell-free assay)	BRD2 (Cell-free assay)	BRD4 (Cell-free assay)
0.25 μM	0.5 μM	0.79 μM

溶解度 *

In vitro	DMSO	Insoluble
	Water	Insoluble
	Ethanol	27 mg/mL (64.99 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.07 mL	120.37 mL	240.73 mL
0.5 mM	4.81 mL	24.07 mL	48.15 mL
1 mM	2.41 mL	12.04 mL	24.07 mL
5 mM	0.48 mL	2.41 mL	4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11783
作用机制	Inhibitor (抑制剂)
M. Wt	415.4
Formula	C23H21N5O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1300031-49-5
Synonyms	GSK1210151A
SMILES	CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[C@H](C)C5=CC=CC=N5)OC