GSK-3

Catalog No.Inhibitor Name GSK-3 GSK-3α GSK-3β Other Targets
A10825SB216763
**
**
A11085CHIR-98014
****
****
Cdc2
A11223TWS119
**
A11592Tideglusib
*
A11061SB415286
*
*
A10199CHIR-99021
***
****
A13060AZD2858
*
A12819AZD1080
***
**
A13728AR-A014418
**
A11941TDZD-8
*
A12741LY2090314
****
****
A15555BIO-acetoxime
***
***
A14196IM-12
**
A10471Indirubin
*
CDK2/CyclinA,CDK5/p35,CDK1/CyclinB
A15526Bikinin
A143031-Azakenpaullone
A16280Indirubin-3-monoxime
***
CDK1/5
A16230CP21R7

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. CHIR-99021

    Catalog No. A10199
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    GSK-3 抑制剂
    CHIR99021是一种GSK-3α和GSK-3β抑制剂,IC50值分别为10和6.7 nM。 了解更多
  2. Indirubin-3-monoxime

    Catalog No. A16280
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    GSK-3β 抑制剂
    Indirubin-3'-monoxime是一种功能强大的GSK-3β抑制剂,IC50为22nM,也抑制CDK1/5(IC50 = 180/100 nM)。 了解更多
  3. CP21R7

    Catalog No. A16230
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    GSK-3β 抑制剂
    CP21R7是有效的选择性GSK-3β抑制剂。 了解更多
  4. AZD1080

    Catalog No. A12819
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    GSK3 抑制剂
    AZD1080是一种新型GSK3抑制剂,可消除啮齿动物大脑中的突触可塑性缺陷,并在人类中表现出外周靶标参与。 了解更多
  5. GSK-3b

    Catalog No. A15471
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    GSK-3 beta 抑制剂
  6. AR-A 014418

    Catalog No. A13728
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    GSK-3 抑制剂
    AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5(IC50值> 100μM)以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。 了解更多
  7. BIO-acetoxime

    Catalog No. A15555
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    GSK-3 抑制剂
    BIO-acetoxime是一种有效的双重GSK3α/β抑制剂,IC50为10 nM,选择性比CDK5/p25,CDK2/cyclin A和 CDK1/cyclin B高240倍以上。 了解更多
  8. GSK-3 inhibitor 1

    Catalog No. A21803
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    GSK-3 inhibitor
    GSK-3 inhibitor 1 is an inhibitor of GSK-3. 了解更多
  9. VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多
  10. CHIR-99021 trihydrochloride

    Catalog No. A21436
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    GSK-3α/β inhibitor
    CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. 了解更多
  11. CHIR-99021 monohydrochloride

    Catalog No. A21430
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    GSK-3α/β inhibitor
    CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. 了解更多
  12. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多
    • 最新产品

    BIO

    Catalog No. A17129
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    GSK3 抑制剂
    BIO是一种细胞可渗透的双吲哚(靛玉红)化合物,可作为GSK3α/β的强效,选择性,可逆和ATP竞争性抑制剂。IC50值为5 nM。 了解更多
  13. Bikinin

    Catalog No. A15526
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    GSK-3 抑制剂
    Bikinin是植物GSK-3/Shaggy-like激酶的有效抑制剂。激活BR受体下游的BR信号传导。 了解更多
  14. IM-12

    Catalog No. A14196
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    GSK-3β 抑制剂
    IM-12是一种细胞渗透性吲哚标记,作为糖原合成酶激酶3β(GSK-3β)抑制剂,激活典型Wnt信号的下游成分。 了解更多
  15. 1-Azakenpaullone

    Catalog No. A14303
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    GSK-3β 抑制剂
    1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂,IC50为18 nM,选择性比CDK1/cyclin B和CDK5/p25高100倍。 了解更多
  16. AZD2858

    Catalog No. A13060
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    GSK-3β 抑制剂
    AZD2858是一种选择性GSK-3抑制剂,IC50为68 nM,激活Wnt信号,增加大鼠的骨量。 了解更多
  17. LY2090314

    Catalog No. A12741
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    GSK-3 抑制剂
    LY2090314是糖原合酶激酶3(GSK-3)的有效抑制剂,在许多途径中起重要作用,包括蛋白质合成的起始,细胞增殖,细胞分化和凋亡。 了解更多
  18. Tideglusib

    Catalog No. A11592
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    GSK-3 抑制剂
    Tideglusib是一种不可逆的,非ATP竞争性的GSK-3β抑制剂,无细胞试验中IC50为60 nM。用于治疗阿尔茨海默氏病和进行性核上性麻痹。 了解更多
  19. TDZD-8

    Catalog No. A11941
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    GSK-3 抑制剂
    TDZD-8是一种非ATP竞争性GSK-3β抑制剂,IC50为2 μM;对CDK1, casein kinase II, PKA和PKC具有最低限度的抑制效果。 了解更多
  20. TWS119

    Catalog No. A11223
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    GSK-3 抑制剂
    TWS119是4,6双取代的吡咯并嘧啶,可有效抑制GSK3β,IC50值为30 nM。 了解更多
  21. CHIR-98014

    Catalog No. A11085
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    GSK-3 抑制剂
    CHIR-98014是一种非常有效的,选择性的,细胞可渗透的GSK-3抑制剂。 了解更多
  22. SB 415286

    Catalog No. A11061
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    GSK-3 抑制剂
    SB 415286是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂,IC50值为78 nM(与GSK3β相似的效价),Ki值为31 nM。 了解更多
  23. SB 216763

    Catalog No. A10825
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    GSK-3 抑制剂
    SB 216763是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂,IC50值为34 nM(与GSK3β相似的效力)。 了解更多
  24. Indirubin

    Catalog No. A10471
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    CDK & GSK-3β 抑制剂
    Indirubin是中国抗白血病药物的活性成分,是一种有效的细胞周期蛋白依赖性激酶和GSK-3β抑制剂,IC50约为5 μM和0.6 μM。 了解更多

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