GSK2126458 (Omipalisib)

Name: GSK2126458 (Omipalisib)
SKU: A11035

目录号: A11035

mTOR/PI3K 抑制剂,

GSK2126458 (Omipalisib) Chemical Structure

CAS NO. 1086062-66-9

GSK2126458 (Omipalisib)是一种高选择性的，有效的p110α/β/γ/δ和 mTORC1/2抑制剂，无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。

库存：现货

规格	价格	数量
2 mg	￥ 800.00
5 mg	￥ 1,200.00
10 mg	￥ 1,600.00
50 mg	￥ 4,200.00
10mM * 1mL in DMSO	￥ 1,300.00

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生物活性

GSK2126458 (Omipalisib)是一种高选择性的，有效的p110α/β/γ/δ和 mTORC1/2抑制剂，无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。

Targets

Target	Value
p110α	ki: 0.019nM
p110δ	ki: 0.024nM
p110γ	ki: 0.06nM
p110β	ki: 0.13nM
mTORC1	ki: 0.18nM
mTORC2	ki: 0.3nM

溶解度 *

In vitro (25°C)	DMSO	96 mg/mL (189.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.78 mL	98.91 mL	197.82 mL
0.5 mM	3.96 mL	19.78 mL	39.56 mL
1 mM	1.98 mL	9.89 mL	19.78 mL
5 mM	0.4 mL	1.98 mL	3.96 mL

*The above data is based on the productmolecular weight 505.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11035
作用机制	Inhibitor (抑制剂)
M. Wt	505.5
Formula	C25H17F2N5O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1086062-66-9
Synonyms	GSK-2126458
SMILES	COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F