GSK429286A

目录号: A10441

ROCK 抑制剂

GSK429286A

GSK429286A Chemical Structure

CAS NO. 864082-47-3

GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。

库存: 现货

规格 价格 数量
5 mg
¥ 800.00
25 mg
¥ 2,080.00
50 mg
¥ 3,600.00
100 mg
¥ 5,800.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。
靶点信息
ROCK1 ROCK2
14 nM63 nM
In vitro (25°C) DMSO 81 mg/mL (187.33 mM)
Water Insoluble
Ethanol 4 mg/mL (9.25 mM)
In vivo 15% Captisol+citrate vehicle 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.13 mL 115.63 mL 231.27 mL
0.5 mM 4.63 mL 23.13 mL 46.25 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10441
作用机制 Inhibitor (抑制剂)
M. Wt 432.4
Formula C21H16F4N4O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 864082-47-3
Synonyms GSK-429286A
SMILES CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F

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