GW788388

Name: GW788388
SKU: A11083

目录号: A11083

TGF-beta/Smad 抑制剂

GW788388 Chemical Structure

CAS NO. 452342-67-5

GW788388是有效的，口服活性的，选择性的转化生长因子β受体I（TGF-βR1）（激活素受体样激酶5，ALK5）抑制剂,无细胞试验中IC50为18 nM，也抑制TGF-βII型受体和activin II型受体活性，但不抑制BMP II型受体。

库存：现货

规格	价格	数量
5 mg	￥ 380.00
10 mg	￥ 600.00
50 mg	￥ 2,000.00
100 mg	￥ 3,600.00
10mM * 1mL in DMSO	￥ 910.00

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产品详情

生物活性

靶点信息

ALK5 (Cell-free assay)
18 nM

溶解度 *

In vitro (25°C)	DMSO	15 mg/mL (35.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.5 mL	117.51 mL	235.02 mL
0.5 mM	4.7 mL	23.5 mL	47 mL
1 mM	2.35 mL	11.75 mL	23.5 mL
5 mM	0.47 mL	2.35 mL	4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11083
作用机制	Inhibitor (抑制剂)
M. Wt	425.5
Formula	C25H23N5O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	452342-67-5
Synonyms	GW-788388
SMILES	C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5