HCV Protease

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. MK-5172 hydrate

    Catalog No. A15166
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    HCV Protease 抑制剂
    MK-5172 hydrate是目前正在临床开发中的新型P2-P4喹喔啉大环HCV NS3/4a蛋白酶抑制剂。 了解更多
  2. MK-5172 potassium salt

    Catalog No. A15167
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    HCV Protease 抑制剂
    MK-5172 potassium salt是新型P2-P4喹喔啉大环HCV NS3/4a蛋白酶抑制剂。 了解更多
  3. MK-5172 sodium salt

    Catalog No. A15168
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    HCV Protease 抑制剂
    MK-5172 sodium salt是目前正在临床开发中的新型P2-P4喹喔啉大环HCV NS3/4a蛋白酶抑制剂。 了解更多
  4. RO-9187

    Catalog No. A15224
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    HCV replication 抑制剂
    RO-9187是复制系统中HCV病毒复制的有效抑制剂(IC(50)= 171+/-12 nM;CC(50)> 1 mM)。 了解更多
  5. VCH-759

    Catalog No. A15479
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    HCV Polymerase 抑制剂
    VCH-759是HCV RNA依赖性聚合酶的非核苷抑制剂,相对于基因型1a/1b复制子,具有亚微摩尔IC50值。 了解更多
  6. Nesbuvir

    Catalog No. A11510
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    HCV Polymerase 抑制剂
    Nesbuvir是丙型肝炎病毒(HCV) NS5B RNA依赖性RNA聚合酶的选择性抑制剂。 了解更多
  7. Simeprevir

    Catalog No. A11580
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    HCV NS3/4A protease 抑制剂
    Simeprevir是HCV NS3/4A蛋白酶(Ki = 0.36 nM)和病毒复制(replicon EC50 = 7.8 nM)的有效抑制剂。 了解更多
  8. Vaniprevir

    Catalog No. A11600
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    HCV NS3/4A protease 抑制剂
    Vaniprevir是丙型肝炎病毒(HCV)NS3/4A蛋白酶的非共价竞争性抑制剂。 了解更多
  9. Velpatasvir

    Catalog No. A17302
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    HCV NS5A inhibitor
    Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. 了解更多
  10. Ombitasvir (ABT-267)

    Catalog No. A17624
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    HCV NS5A inhibitor
    Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. 了解更多
  11. Paritaprevir (ABT-450)

    Catalog No. A17625
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    HCV NS3/4A inhibitor
    Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. 了解更多
  12. Ledipasvir acetone

    Catalog No. A18055
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    HCV NS5A inhibitor
    Ledipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. 了解更多
  13. Voxilaprevir

    Catalog No. A12067
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    HCV NS 3/4A protease inhibitor
    Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs). 了解更多
  14. PSI-7409

    Catalog No. A13962
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    nucleotide analog HCV inhibitor
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. 了解更多
  15. Mericitabine

    Catalog No. A11539
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    HCV NS5B polymerase inhibitor
    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. 了解更多
  16. R-1479

    Catalog No. A11540
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    HCV replication inhibitor
    R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). 了解更多
  17. PSI-352938

    Catalog No. A21253
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    HCV nucleotide inhibitor
    PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor. 了解更多
  18. Beclabuvir

    Catalog No. A21511
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    HCV NS5B RNA-dependent RNA polymerase inhibitor
    Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. 了解更多
  19. PSI-7976

    Catalog No. A21631
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    HCV RNA replication inhibitor
    PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. 了解更多
  20. Sofosbuvir impurity C

    Catalog No. A21636
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    HCV RNA replication inhibitor
    Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. 了解更多
  21. Sofosbuvir impurity A

    Catalog No. A21641
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    HCV RNA replication inhibitor
    Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity. 了解更多
  22. NM107

    Catalog No. A21761
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    HCV NS5B polymerase
    NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM. 了解更多
  23. PSI-6206 13CD3

    Catalog No. A21782
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    HCV NS5B polymerase inhibitor
    PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. 了解更多
  24. HCV-IN-3

    Catalog No. A20957
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    HCV NS3/4a protein inhibitor
    HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. 了解更多
  25. GS-9451

    Catalog No. A14046
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    HCV NS3/4A protease 抑制剂
    GS-9451是一种新型的丙型肝炎病毒(HCV)非结构性3/4a(NS3/4a)蛋白酶抑制剂,在感染HCV基因型1(GT 1)的患者中具有很高的活性。 了解更多
  26. MK 8742 (elbasvir)

    Catalog No. A13965
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    HCV NS5A 抑制剂
    MK 8742 (elbasvir)是HCV NS5A抑制剂,是一种用于治疗HCV感染的全口服,无干扰素的治疗方案。 了解更多
  27. Faldaprevir

    Catalog No. A14106
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    HCV Protease 抑制剂
    Faldaprevir是丙型肝炎病毒蛋白酶抑制剂。 了解更多
  28. BMS-790052 (Daclatasvir)

    Catalog No. A10159
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    HCV NS5A 抑制剂
    BMS-790052 (Daclatasvir)是一种高度选择性的HCV NS5A抑制剂,EC50为9-50 pM,用于治疗丙型肝炎病毒(HCV)感染。 了解更多
  29. Danoprevir (RG7227)

    Catalog No. A10284
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    HCV NS3/4A protease 抑制剂
    Danoprevir (RG7227)是HCV NS3/4A丝氨酸蛋白酶的有效抑制剂。 了解更多
  30. VX-222

    Catalog No. A10980
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    HCV Protease 抑制剂
    VX-222是HCV NS5B聚合酶的小分子非核苷抑制剂,正在研究中,用于治疗丙型肝炎病毒感染。 了解更多
  31. Telaprevir (VX-950)

    Catalog No. A10902
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    HCV NS3-4A protease 抑制剂
    Telaprevir (VX-950)被称为蛋白酶抑制剂,可抑制丙型肝炎病毒NS3.4A丝氨酸蛋白酶。 了解更多
  32. Anguizole

    Catalog No. A11294
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    HCV replication 抑制剂
    Anguizole是一种抑制HCV复制并改变NS4B亚细胞分布的小分子。 了解更多
  33. Asunaprevir (BMS-650032)

    Catalog No. A11295
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    NS3 protease 抑制剂
    Asunaprevir是病毒酶丝氨酸蛋白酶NS3的抑制剂。 了解更多
  34. Boceprevir (SCH-503034)

    Catalog No. A11332
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    HCV Protease 抑制剂
    Boceprevir (SCH-503034)是一种蛋白酶抑制剂,可用于治疗C型肝炎基因型1。 了解更多
  35. Balapiravir (R1626)

    Catalog No. A11335
    Polymerase 抑制剂
    Balapiravir (R1626)是丙型肝炎病毒(HCV) RNA依赖性rna聚合酶(R1479,RG1479)核苷类似物抑制剂的前药。 了解更多
  36. BMS-790052 2HCl

    Catalog No. A11336
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    NS5A 抑制剂
    BMS-790052 2HCl是一种NS5A抑制剂,用于治疗丙型肝炎病毒(HCV)感染。 了解更多
  37. Ciluprevir (BILN 2061)

    Catalog No. A11343
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    HCV NS3 protease 抑制剂
    Ciluprevir (BILN 2061)是HCV NS3蛋白酶的一种特定而有效的拟肽抑制剂。 了解更多
  38. PSI-6130

    Catalog No. A11519
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    HCV Nucleoside 抑制剂
    PSI-6130是丙型肝炎病毒核苷抑制剂。 了解更多
  39. Tegobuvir (GS-9190)

    Catalog No. A11583
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    NS5B polymerase 抑制剂
    Tegobuvir (GS-9190)是一种非核苷NS5B聚合酶抑制剂。 了解更多
  40. VCH-916

    Catalog No. A12374
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    HCV NS5B polymerase 抑制剂
    VCH-916是一种新型非核苷HCV NS5B聚合酶抑制剂。 了解更多
  41. Setrobuvir (ANA-598)

    Catalog No. A13105
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    HCV Polymerase 抑制剂
    Setrobuvir (ANA-598)是一种直接作用的抗病毒药物或DAA,是HCV RNA聚合酶的一种非核苷抑制剂。 了解更多
  42. Celgosivir

    Catalog No. A13118
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    alpha-glucosidase I 抑制剂
    Celgosivir是一种用于潜在治疗HCV感染的α-葡萄糖苷酶I抑制剂。 了解更多
  43. Ledipasvir (GS 5885)

    Catalog No. A13155
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    NS5A 抑制剂
    Ledipasvir (GS 5885)是丙型肝炎病毒HCV NS5A蛋白的抑制剂。 了解更多
  44. Glecaprevir

    Catalog No. A16948
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    HCV NS3/4A protease 抑制剂
    Glecaprevir,也称为ABT-493和A-1282576,是一种新型的HCV NS3/4A蛋白酶抑制剂,IC50值在3.5至11.3 nM之间。 了解更多
  45. PSI-7977

    Catalog No. A11529
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    HCV Nucleotide 抑制剂
    PSI-7977是PSI-7851的氨基磷酸酯前药,PSI-7851是核苷类似物,当磷酸化时,抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。 了解更多
  46. PSI-6206

    Catalog No. A11530
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    HCV RNA polymerase 抑制剂
    PSI-6206是PSI-6130的脱氨基衍生物,是有效的HCV RNA依赖性RNA聚合酶抑制剂,靶向NS5B聚合酶。 了解更多
  47. Narlaprevir

    Catalog No. A11506
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    NS3 protease 抑制剂
    Narlaprevir是一种有效的、选择性的、口服生物可利用的ns3蛋白酶抑制剂(Ki=6 nM;EC90=40 nM)。 了解更多
  48. MK-5172

    Catalog No. A13787
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    HCV NS3/4a 抑制剂
    MK-5172是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂,在基因型和耐药变异中具有广泛的活性。 了解更多
  49. GS-9256

    Catalog No. A13526
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    HCV NS3 抑制剂
    GS-9451是一种有效的大环HCV NS3 PI,在3天单药治疗后,HCV RNA的中值最大变化达到3.6 log10 IU/mL(范围从-4.7 log10到-3.1 log10 IU/mL)。 I期HCV基因型1感染。 了解更多
  50. BI207127 (Deleobuvir)

    Catalog No. A13414
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    HCV NS5B polymerase 抑制剂
    BI 207127是非核苷类丙型肝炎病毒NS5B聚合酶抑制剂,用于治疗丙型肝炎。 了解更多

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