Imatinib (Gleevec)

目录号: A10259

PDGFR 抑制剂

Imatinib (Gleevec)

Imatinib (Gleevec) Chemical Structure

CAS NO. 152459-95-5

Imatinib (Gleevec)是一种多靶点酪氨酸激酶抑制剂,抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6,0.1和0.1 μM。

库存: 现货

规格 价格 数量
250 mg
¥ 500.00
500 mg
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Imatinib (Gleevec)是一种多靶点酪氨酸激酶抑制剂,抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6,0.1和0.1 μM。
靶点信息
PDGFR (Cell-free assay) c-Kit (M-07e cells) v-Abl (Cell-free assay)
100 nM100 nM600 nM
In vitro (25°C) DMSO 28 mg/mL (56.72 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.26 mL 101.3 mL 202.59 mL
0.5 mM 4.05 mL 20.26 mL 40.52 mL
1 mM 2.03 mL 10.13 mL 20.26 mL
5 mM 0.41 mL 2.03 mL 4.05 mL

*The above data is based on the productmolecular weight 493.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10259
作用机制 Inhibitor (抑制剂)
M. Wt 493.6
Formula C29H31N7O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 152459-95-5
Synonyms STI571, Glivec
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
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