Imatinib Mesylate

目录号: A10468

Bcr-Abl 抑制剂

Imatinib Mesylate

Imatinib Mesylate Chemical Structure

CAS NO. 220127-57-1

Imatinib mesylate是一种选择性酪氨酸激酶抑制剂,通过抑制KIT信号转导途径,在治疗胃肠间质瘤中诱导了持续的客观反应。

库存: 现货

规格 价格 数量
100 mg
¥ 600.00
200 mg
¥ 700.00
500 mg
¥ 800.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Imatinib mesylate是一种选择性酪氨酸激酶抑制剂,通过抑制KIT信号转导途径,在治疗胃肠间质瘤中诱导了持续的客观反应。
靶点信息
PDGFR (Cell-free assay) c-Kit (M-07e cells) v-Abl (Cell-free assay)
100 nM100 nM600 nM
In vitro DMSO 101 mg/mL (171.26 mM)
Water 101 mg/mL (171.26 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.96 mL 84.79 mL 169.58 mL
0.5 mM 3.39 mL 16.96 mL 33.92 mL
1 mM 1.7 mL 8.48 mL 16.96 mL
5 mM 0.34 mL 1.7 mL 3.39 mL

*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10468
作用机制 Inhibitor (抑制剂)
M. Wt 589.7
Formula C29H31N7O.CH4SO3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 220127-57-1
Synonyms Gleevec, Glivec, CGP-57148B, STI-571
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

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