产品详情

生物活性

IOX1是2OG加氧酶（包括JmjC脱甲基酶）的有效且广谱抑制剂。

Targets

Target	Value
KDM3A	IC50: 0.1μM
KDM4C	IC50: 0.6μM
KDM6B	IC50: 1.6μM
KDM2A	IC50: 1.8μM
KDM4E	IC50: 2.3μM
KDM5C	IC50: 19μM
PHD2	IC50: 33μM

溶解度 *

In vitro	DMSO	36 mg/mL (190.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	52.86 mL	264.31 mL	528.63 mL
0.5 mM	10.57 mL	52.86 mL	105.73 mL
1 mM	5.29 mL	26.43 mL	52.86 mL
5 mM	1.06 mL	5.29 mL	10.57 mL

*The above data is based on the productmolecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14277
作用机制	Inhibitor (抑制剂)
M. Wt	189.17
Formula	C10H7NO3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	5852-78-8
Synonyms	IOX 1, Iox-1
SMILES	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O