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JH-II-127是一种高效，选择性和脑渗透性的LRRK2抑制剂，对于LRRK2野生型，LRRK2-G2019S和LRRK2-A2016T，IC50为6.6 nM，2.2 nM和47.7 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.99 mL | 119.94 mL | 239.89 mL |
| 0.5 mM | 4.8 mL | 23.99 mL | 47.98 mL |
| 1 mM | 2.4 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
*The above data is based on the productmolecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15777 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 416.86 |
| Formula | C19H21ClN6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1700693-08-8 |
| SMILES | CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC |
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