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JNJ-7706621

CDK/Aurora A/B 抑制剂

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产品目录号: A10494

库存状态:中国现货中国现货

产品名 目录号 价格 数量
JNJ-7706621 5mg A10494-5
¥ 1,200.00
JNJ-7706621 10mg A10494-10
¥ 2,100.00
JNJ-7706621 50mg A10494-50
¥ 5,000.00
JNJ-7706621 100mg A10494-100
¥ 8,600.00
JNJ-7706621 10mM * 1mL in DMSO A10494-10mM-D
¥ 1,540.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

JNJ-7706621

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Chemical Information

目录号 A10494
Mechanism of action Inhibitor
分子量 394.4
化学分子式 C15H12F2N6O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 443797-96-4
Synonyms JNJ7706621
SMILES code C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
化学名称 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1h-1,2,4-triazol-3-yl]amino]benzenesulfonamide

Biological Activity

Description
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Solubility

Solubility (25°C) * In vitro DMSO 79 mg/mL (200.32 mM)
Water <1 mg/mL (<1 mM
Ethanol <1 mg/mL (<1 mM
In vivo 0.5% methylcellulose/0.2% Tween 80 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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