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Kinesin

Inhibitory Selectivity
Catalog No.Inhibitor Name Kinesin
A10486Ispinesib
***
A10828SB743921
****
A11170AZ 3146
*
A11435GSK923295
**
A14290MPI-0479605
***
A14234ARQ 621

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11050

Arry-520 (Filanesib)

KSP 抑制剂
KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5) with potential antineoplastic activity.
A15844 SALE

K 858

Kinesin Eg5 抑制剂
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM.
A15841 SALE

Dimethylenastron

Kinesin Eg5 抑制剂
Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.
A15001

ARRY-520 R enantiomer

KSP 抑制剂
ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
A14290

MPI-0479605

Mps1 抑制剂
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1
A14234

ARQ 621

Eg5 mitotic motor protein 抑制剂
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.
A13735

CW069

Microtubule Associated 抑制剂
CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
A11435 SALE

GSK-923295

CENP-E 抑制剂
GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E).
A11976

Monastrol

Kinesin-5(KIF11) 抑制剂
Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 ?M) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
A10828 SALE

SB 743921

KSP 抑制剂
SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
A11170 SALE

AZ 3146

Mps1 抑制剂

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

A10486 SALE

Ispinesib (SB-715992)

KSP 抑制剂
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
A15956

EMD534085

Kinesin 抑制剂
EMD534085 is a kinesin inhibitor currently in clinical development.

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