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KM 11060纠正了F508del-CFTR的运输，增加了质膜上功能性CFTR的量（?75％）并抑制了PDE5的活性。
| In vitro | DMSO | 81 mg/mL (191.79 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (4.73 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.68 mL | 118.39 mL | 236.78 mL |
| 0.5 mM | 4.74 mL | 23.68 mL | 47.36 mL |
| 1 mM | 2.37 mL | 11.84 mL | 23.68 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
*The above data is based on the productmolecular weight 422.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15843 |
|---|---|
| M. Wt | 422.33 |
| Formula | C19H17Cl2N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 774549-97-2 |
| Synonyms | KM-11060, KM11060 |
| SMILES | O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C(Cl)C=C4)=O |
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