Lonafarnib (SCH66336)

目录号: A12328

FPTase 抑制剂

Lonafarnib (SCH66336)

Lonafarnib (SCH66336) Chemical Structure

CAS NO. 193275-84-2

Lonafarnib (SCH66336)是H-ras、K-ras-4B和N-ras的选择性FPTase抑制剂,IC50分别为1.9 nM、5.2 nM和2.8 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
25 mg
¥ 2,800.00
50 mg
¥ 5,000.00
10mM * 1mL in DMSO
¥ 1,740.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Lonafarnib (SCH66336)是H-ras、K-ras-4B和N-ras的选择性FPTase抑制剂,IC50分别为1.9 nM、5.2 nM和2.8 nM。
靶点信息
H-ras (Cell-free assay) N-ras (Cell-free assay) K-ras-4B (Cell-free assay)
1.9 nM2.8 nM5.2 nM
In vitro DMSO 116 mg/mL (181.58 mM)
Water Insoluble
Ethanol 116 mg/mL (181.58 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.65 mL 78.27 mL 156.54 mL
0.5 mM 3.13 mL 15.65 mL 31.31 mL
1 mM 1.57 mL 7.83 mL 15.65 mL
5 mM 0.31 mL 1.57 mL 3.13 mL

*The above data is based on the productmolecular weight 638.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12328
作用机制 Inhibitor (抑制剂)
M. Wt 638.82
Formula C27H31Br2ClN4O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 193275-84-2
Synonyms Sarasar, SCH 66336, SCH66336, SCH-66336
SMILES C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N

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