LRRK2-IN-1

Name: LRRK2-IN-1
SKU: A11477

目录号: A11477

LRRK2 抑制剂

LRRK2-IN-1 Chemical Structure

CAS NO. 1234480-84-2

LRRK2-IN-1抑制G2019S突变体和野生型LRRK2激酶活性，IC50值分别为6和13 nM。

库存：现货

规格	价格	数量
10 mg	￥ 1,100.00
25 mg	￥ 2,300.00
50 mg	￥ 4,000.00
10mM * 1mL in DMSO	￥ 1,200.00

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产品详情

生物活性

LRRK2-IN-1抑制G2019S突变体和野生型LRRK2激酶活性，IC50值分别为6和13 nM。

Targets

Target	Value
DCLK1	IC50: 2.61nM
LRRK2(G2019S)	IC50: 6nM
LRRK2(WT)	IC50: 13nM
DCLK2	IC50: 45nM
LRRK2(A2016T)	IC50: 2.45μM
LRRK2(A2016T+G2019S)	IC50: 3.08μM

溶解度 *

In vitro (25°C)	DMSO	97 mg/mL (169.96 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (169.96 mM)
In vivo	Captisol	16 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.54 mL	87.71 mL	175.41 mL
0.5 mM	3.51 mL	17.54 mL	35.08 mL
1 mM	1.75 mL	8.77 mL	17.54 mL
5 mM	0.35 mL	1.75 mL	3.51 mL

*The above data is based on the productmolecular weight 570.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11477
作用机制	Inhibitor (抑制剂)
M. Wt	570.09
Formula	C31H38N8O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1234480-84-2
SMILES	CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC