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LY 2183240既可作为内源性大麻素再摄取的有效抑制剂，IC50为270 pM，又可作为脂肪酸酰胺水解酶（FAAH）的抑制剂，IC50为12.4 nM，而脂肪酸酰胺水解酶是负责降解花生四烯酸的主要酶。
| In vitro | DMSO | 56 mg/mL (182.2 mM) | |
| Water | Insoluble | ||
| Ethanol | 56 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.54 mL | 162.68 mL | 325.36 mL |
| 0.5 mM | 6.51 mL | 32.54 mL | 65.07 mL |
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
*The above data is based on the productmolecular weight 307.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11960 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 307.35 |
| Formula | C17H17N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 874902-19-9 |
| Synonyms | LY2183240, LY-2183240 |
| SMILES | CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 |
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