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LY2090314是糖原合酶激酶3（GSK-3）的有效抑制剂，在许多途径中起重要作用，包括蛋白质合成的起始，细胞增殖，细胞分化和凋亡。
靶点信息
| GSK-3β | GSK-3α | |||
| 0.9 nM | 1.5 nM |
| In vitro (25°C) | DMSO | 93 mg/mL (181.45 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 2 mg/mL (3.9 mM) | ||
| In vivo | 5% DMSO+45% PEG 300+ddH2O | 16 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.51 mL | 97.56 mL | 195.11 mL |
| 0.5 mM | 3.9 mL | 19.51 mL | 39.02 mL |
| 1 mM | 1.95 mL | 9.76 mL | 19.51 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
*The above data is based on the productmolecular weight 512.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12741 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 512.53 |
| Formula | C28H25FN6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 603288-22-8 |
| Synonyms | LY 2090314, LY-2090314 |
| SMILES | C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7 |
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