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LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。
靶点信息
| p38α (Cell-free assay) | ||||
| 7 nM |
| In vitro (25°C) | DMSO | Warmed: 4 mg/mL (6.52 mM) | |
| Water | Warmed: 91 mg/mL (148.51 mM) | ||
| Ethanol | 3 mg/mL (4.89 mM) | ||
| In vivo | Saline | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.32 mL | 81.61 mL | 163.21 mL |
| 0.5 mM | 3.26 mL | 16.32 mL | 32.64 mL |
| 1 mM | 1.63 mL | 8.16 mL | 16.32 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
*The above data is based on the productmolecular weight 612.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10545 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 612.7 |
| Formula | C24H29FN6.2CH4O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 862507-23-1 |
| Synonyms | LY-2228820 |
| SMILES | CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O |
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