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LY2608204是治疗2型糖尿病的有效药物。是葡萄糖激酶（GK）活化剂，EC50为42 nM。
靶点信息
| glucokinase | ||||
| 42 nM(EC50) |
| In vitro (25°C) | DMSO | 95 mg/mL (169.69 mM) | |
| Water | Insoluble | ||
| Ethanol | 30 mg/mL (53.59 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.86 mL | 89.32 mL | 178.64 mL |
| 0.5 mM | 3.57 mL | 17.86 mL | 35.73 mL |
| 1 mM | 1.79 mL | 8.93 mL | 17.86 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.57 mL |
*The above data is based on the productmolecular weight 559.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11406 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 559.8 |
| Formula | C28H37N3O3S3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1234703-40-2 |
| Synonyms | LY-2608204 |
| SMILES | C1CCC(CC1)[C@@H]2C[C@@]2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6 |
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