LY2784544 (Gandotinib)

目录号: A10546

JAK 抑制剂

LY2784544 (Gandotinib)

LY2784544 (Gandotinib) Chemical Structure

CAS NO. 1229236-86-5

LY2784544被鉴定为对JAK2-V617F具有高度选择性,并已进入人类临床试验,用于治疗几种骨髓增生性疾病。

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,600.00
25 mg
¥ 3,200.00
100 mg
¥ 9,000.00
10mM * 1mL in DMSO
¥ 1,440.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

LY2784544被鉴定为对JAK2-V617F具有高度选择性,并已进入人类临床试验,用于治疗几种骨髓增生性疾病。
Targets
Target Value
JAK2(V617F)ki: 0.245nM
JAK2ki: 0.288nM
JAK2IC50: 2.52nM
FLT3IC50: 4nM
JAK1IC50: 19.8nM
FLT4IC50: 25nM
FGFR2IC50: 32nM
TYK2IC50: 44nM
JAK3IC50: 48.0nM
TrkBIC50: 95nM
FGFR3IC50: 106nM
KDRIC50: 109nM
ALKIC50: 138nM
MUSKIC50: 147nM
AuroraAIC50: 168nM
MAP3K9IC50: 299nM
In vitro DMSO 92 mg/mL (195.76 mM)
Water Insoluble
Ethanol 9 mg/mL (19.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.28 mL 106.41 mL 212.81 mL
0.5 mM 4.26 mL 21.28 mL 42.56 mL
1 mM 2.13 mL 10.64 mL 21.28 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10546
作用机制 Inhibitor (抑制剂)
M. Wt 469.9
Formula C23H25ClFN7O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1229236-86-5
SMILES CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F

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