LY364947

目录号: A13446

TGFβR-I 抑制剂

LY364947

LY364947 Chemical Structure

CAS NO. 396129-53-6

LY364947是一种二杂芳基取代的吡唑类化合物,用作TGF-βRI(TGF-β受体I激酶)的选择性ATP竞争性抑制剂。

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,200.00
50 mg
¥ 2,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

LY364947是一种二杂芳基取代的吡唑类化合物,用作TGF-βRI(TGF-β受体I激酶)的选择性ATP竞争性抑制剂。
靶点信息
TGFβRI (Cell-free assay) RIPK2 (Cell-free assay) CK1δ (Cell-free assay) TGFβRII (Cell-free assay) MLK-7K (Cell-free assay)
59 nM0.11 μM0.22 μM0.4 μM1.4 μM
In vitro (25°C) DMSO 1 mg/mL (3.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 0.71 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.72 mL 183.62 mL 367.24 mL
0.5 mM 7.34 mL 36.72 mL 73.45 mL
1 mM 3.67 mL 18.36 mL 36.72 mL
5 mM 0.73 mL 3.67 mL 7.34 mL

*The above data is based on the productmolecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13446
作用机制 Inhibitor (抑制剂)
M. Wt 272.3
Formula C17H12N4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 396129-53-6
Synonyms HTS 466284 ,TGF-β RI Kinase Inhibitor
SMILES C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

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