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Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂，IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。
靶点信息
| ET-A | ET-B | |||
| 0.5 nM | 391 nM |
| In vitro | DMSO | 87 mg/mL (147.88 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17 mL | 84.99 mL | 169.99 mL |
| 0.5 mM | 3.4 mL | 17 mL | 34 mL |
| 1 mM | 1.7 mL | 8.5 mL | 17 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11492 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 588.27 |
| Formula | C19H20Br2N6O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 441798-33-0 |
| Synonyms | ACT 064992, ACT-064992, ACT064992 |
| SMILES | CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br |
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