Maraviroc (UK-427857)

Name: Maraviroc (UK-427857)
SKU: A10556

目录号: A10556

CCR 拮抗剂

Product Citations (3)

Maraviroc (UK-427857) Chemical Structure

CAS NO. 376348-65-1

Maraviroc (UK-427857)是CCR5受体拮抗剂类别的抗逆转录病毒药物，用于治疗HIV感染。

库存：现货

规格	价格	数量
5 mg	￥ 400.00
25 mg	￥ 1,800.00
50 mg	￥ 3,200.00
100 mg	￥ 5,800.00
10mM * 1mL in DMSO	￥ 1,000.00

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生物活性

Maraviroc (UK-427857)是CCR5受体拮抗剂类别的抗逆转录病毒药物，用于治疗HIV感染。

靶点信息

MIP-1α (Cell-free assay)	RANTES (Cell-free assay)	MIP-1β (Cell-free assay)
3.3 nM	5.2 nM	7.2 nM

溶解度 *

In vitro (25°C)	DMSO	91 mg/mL (177.15 mM)
	Water	Insoluble
	Ethanol	91 mg/mL (177.15 mM)
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.33 mL	194.67 mL
0.5 mM	3.89 mL	19.47 mL	38.93 mL
1 mM	1.95 mL	9.73 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10556
作用机制	Antagonist (拮抗剂)
M. Wt	513.7
Formula	C29H41F2N5O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	376348-65-1
Synonyms	UK-427857, Celsentri
SMILES	CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C