MEK162 (ARRY-438162, Binimetinib)

目录号: A11493

MEK1/2 抑制剂

MEK162 (ARRY-438162, Binimetinib)

MEK162 (ARRY-438162, Binimetinib) Chemical Structure

CAS NO. 606143-89-9

MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 600.00
50 mg
¥ 900.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

MEK162 (ARRY-438162,Binimetinib)是MEK1/2的一种强效、选择性ATP非竞争性抑制剂。
靶点信息
MEK
12 nM
In vitro (25°C) DMSO Warmed: 86 mg/mL (194.91 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% CMC+0.5% Tween-80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.73 mL 113.64 mL 227.27 mL
0.5 mM 4.55 mL 22.73 mL 45.45 mL
1 mM 2.27 mL 11.36 mL 22.73 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 440.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11493
作用机制 Inhibitor (抑制剂)
M. Wt 440.0
Formula C17H15BrF2N4O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 606143-89-9
Synonyms ARRY-162, MEK-162, MEK 162
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

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