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Memantine hydrochloride是nmda受体的拮抗剂，与离子通道位点结合。它还是CYP2B6和CYP2D6抑制剂，作用于重组CYP2B6和CYP2D6，Ki分别为0.51 nM和94.9 μM。它被用于治疗帕金森综合征。
| In vitro | DMSO | 40 mg/mL (185.39 mM) | |
| Water | 28 mg/mL (129.77 mM) | ||
| Ethanol | 40 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 46.34 mL | 231.7 mL | 463.39 mL |
| 0.5 mM | 9.27 mL | 46.34 mL | 92.68 mL |
| 1 mM | 4.63 mL | 23.17 mL | 46.34 mL |
| 5 mM | 0.93 mL | 4.63 mL | 9.27 mL |
*The above data is based on the productmolecular weight 215.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11708 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 215.8 |
| Formula | C12H21N.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 41100-52-1 |
| Synonyms | Namenda |
| SMILES | CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl |
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