MGCD-265 (Glesatinib)

目录号: A10587

c-Met 抑制剂

MGCD-265 (Glesatinib)

MGCD-265 (Glesatinib) Chemical Structure

CAS NO. 875337-44-3

MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂,可与多种RTK(包括c-Met受体(HGFR)结合并抑制其磷酸化。Tek/Tie-2受体;VEGFR类型1、2和3;和MST1R。

库存: 现货

规格 价格 数量
5 mg
¥ 1,200.00
10 mg
¥ 2,200.00
50 mg
¥ 6,500.00
100 mg
¥ 9,800.00
10mM * 1mL in DMSO
¥ 2,140.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂,可与多种RTK(包括c-Met受体(HGFR)结合并抑制其磷酸化。Tek/Tie-2受体;VEGFR类型1、2和3;和MST1R。
Targets
Target Value
MetIC50: 1nM
RONIC50: 2nM
VEGFR1IC50: 3nM
VEGFR2IC50: 3nM
VEGFR3IC50: 4nM
Tie-2IC50: 7nM
In vitro DMSO 99 mg/mL (191.26 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.32 mL 96.6 mL 193.2 mL
0.5 mM 3.86 mL 19.32 mL 38.64 mL
1 mM 1.93 mL 9.66 mL 19.32 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 517.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10587
作用机制 Inhibitor (抑制剂)
M. Wt 517.6
Formula C26H20FN5O2S2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 875337-44-3
Synonyms MGCD265
SMILES CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F

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