MK-2206 2HCl

Name: MK-2206 2HCl
SKU: A10003

目录号: A10003

AKT 抑制剂

Product Citations (17)

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MK-2206 2HCl Chemical Structure

CAS NO. 1032350-13-2

MK-2206 2HCl是Akt1/2/3的高选择性抑制剂，IC50分别为8 nM/12 nM/65 nM。

库存：现货

规格	价格	数量
5 mg	￥ 600.00
10 mg	￥ 720.00
25 mg	￥ 1,150.00
50 mg	￥ 1,620.00
10mM * 1mL in DMSO	￥ 800.00

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生物活性

MK-2206 2HCl是Akt1/2/3的高选择性抑制剂，IC50分别为8 nM/12 nM/65 nM。

靶点信息

Akt1 (Cell-free assay)	Akt2 (Cell-free assay)	Akt3 (Cell-free assay)
8 nM	12 nM	65 nM

溶解度 *

In vitro (25°C)	DMSO	12 mg/mL (24.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5%Tween80+ 50%H2O	0.59 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.82 mL	104.08 mL	208.16 mL
0.5 mM	4.16 mL	20.82 mL	41.63 mL
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL

*The above data is based on the productmolecular weight 480.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10003
作用机制	Inhibitor (抑制剂)
M. Wt	480.4
Formula	C25H21N5O.2HCl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1032350-13-2
Synonyms	MK2206
SMILES	C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl