Monomethyl auristatin E

Name: Monomethyl auristatin E
SKU: A12954

目录号: A12954

Product Citations (1)

Monomethyl auristatin E Chemical Structure

CAS NO. 474645-27-7

Monomethyl auristatin E是一种抗有丝分裂剂，可通过阻止微管蛋白的聚合来抑制细胞分裂，并且还表现出对抗体-药物偶联物（ADCs）活性的抑制作用。

库存：现货

规格	价格	数量
5 mg	￥ 1,200.00
10 mg	￥ 1,800.00
25 mg	￥ 2,800.00
50 mg	￥ 4,800.00

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生物活性

Monomethyl auristatin E是一种抗有丝分裂剂，可通过阻止微管蛋白的聚合来抑制细胞分裂，并且还表现出对抗体-药物偶联物（ADCs）活性的抑制作用。

溶解度 *

In vitro	DMSO	93 mg/mL (129.52 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (129.52 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.64 mL	139.28 mL
0.5 mM	2.79 mL	13.93 mL	27.86 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

*The above data is based on the productmolecular weight 717.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12954
作用机制	Stimulator (刺激物)
M. Wt	717.98
Formula	C39H67N5O7
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	474645-27-7
Synonyms	Monomethylauristatin E, MMAE
SMILES	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC