COX

Catalog No.Inhibitor Name COXCOX-1COX-2Other
A10193Celecoxib
****
A10461Ibuprofen
*
*
A10474Indomethacin
**
*
A11918Rofecoxib
****
A10304Diclofenac Sodium
***
***
A11695Lornoxicam
****
****
A10623Naproxen Sodium
*
*
A13342Valdecoxib
****
A11693Tolfenamic Acid
***
A16399Amfenac Sodium Monohydrate
**
***
A11694Nimesulide
*
A12520Meclofenamate Sodium
****
***
A16428Carprofen
****
A10636Nepafenac
A10878Sulindac
A10565Meloxicam
A10820Aspirin
A11906Phenacetin
A10736Piroxicam
A10462Ibuprofen Lysine
A11641Pranoprofen
A10090Asaraldehyde
A11692Acemetacin
A13244Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 64个

每页
页面:
  1. 1
  2. 2

设置升序顺序
  1. NS-398

    Catalog No. A13116
    Quick View
    COX-2 抑制剂?
    NS-398是具有镇痛和解热作用的非甾体类抗炎药,可选择性抑制前列腺素G / H合酶2 /环氧合酶2(COX-2)活性,IC50为3.8μM,对COX无影响 了解更多
  2. Bromfenac sodium

    Catalog No. A13244
    Quick View
    COX-2 抑制剂
    Bromfenac sodium是一种局部选择性环氧合酶(COX)-2抑制剂 了解更多
  3. Acetaminophen

    Catalog No. A10030
    Quick View
    COX 抑制剂
    Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂,IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。 了解更多
  4. Naproxen sodium

    Catalog No. A10623
    Quick View
    COX 抑制剂
    Naproxen sodium是一种非选择性的环氧合酶(COX)抑制剂,具有抗炎,解热和镇痛作用。对秋水仙碱引起的认知障碍和氧化应激具有神经保护作用。 了解更多
  5. FK 3311

    Catalog No. A13332
    Quick View
    COX-2 抑制剂
    FK3311是一种可渗透细胞且可口服的磺酰苯胺,可作为选择性COX-2抑制剂和NSAID。 了解更多
  6. Flufenamic acid

    Catalog No. A13333
    Quick View
    COX 抑制剂
    Flufenamic acid是一种非甾体类抗炎药(NSAID)。抑制钙激活的氯离子通道(CaCC)。也增加通过TRPC6通道的电流,并抑制通过TRPC3和TRPC7通道的电流。 了解更多
  7. Valdecoxib

    Catalog No. A13342
    Quick View
    COX-2 抑制剂
    伐地考昔(Valdecoxib),也称为SC-65872,是一种非甾体类抗炎药(NSAID),用于治疗骨关节炎,类风湿性关节炎以及痛经和月经症状。 它是一种选择性的环氧合酶2(COX-2)抑制剂,IC50为5nM。 了解更多
  8. Parecoxib

    Catalog No. A13572
    Quick View
    COX-2 抑制剂
    Parecoxib是一种有效的选择性COX-2抑制剂。 了解更多
  9. Pranoprofen

    Catalog No. A11641
    Quick View
    COX 抑制剂
    Pranoprofen是一种用于眼科的非甾体类抗炎药。 了解更多
  10. (-)-Epicatechin

    Catalog No. A12043
    Quick View
    COX-1 抑制剂
    (-)-Epicatechin是绿茶的天然产物。(-)表儿茶素是cox-1的抑制剂。 了解更多
  11. ATB 346

    Catalog No. A13983
    Quick View
    COX-2 抑制剂
    ATB-346具有类似于萘普生的抗炎特性,但其胃肠道毒性显着降低。 了解更多
  12. Meclofenamate Sodium

    Catalog No. A12520
    Quick View
    COX 抑制剂
    Meclofenamate Sodium是一种双重COX-1/COX-2抑制剂,IC50为40 nM和50 nM。 了解更多
  13. Paradol

    Catalog No. A15205
    Quick View
    COX-1 抑制剂
    Paradol是几内亚胡椒(Aframomum melegueta)种子的活性风味成分。已发现Paradol具有抗氧化和抗肿瘤的促进作用。 了解更多
  14. Etoricoxib

    Catalog No. A13770
    Quick View
    COX-2 抑制剂
    Etoricoxib特异性结合并抑制环氧合酶2(COX-2),从而抑制花生四烯酸向前列腺素的转化。抑制COX-2可以诱导细胞凋亡并抑制肿瘤细胞的增殖和血管生成。 了解更多
  15. Xanthohumol

    Catalog No. A15919
    Quick View
    COX 抑制剂
    Xanthohumol是一种来自啤酒花的烯丙基查尔酮,可抑制COX-1和COX-2活性并显示化学预防作用。 了解更多
  16. SC 560

    Catalog No. A13023
    Quick View
    COX-1 抑制剂
    SC 560是一种COX-1选择性抑制剂,IC50 值为9 nM。可以用作研究COX-1衍生的PG在炎症和疼痛中的作用的药理学工具。 了解更多
  17. Etodolac (AY-24236)

    Catalog No. A10371
    Quick View
    COX inhibitor
    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). 了解更多
  18. Tenidap

    Catalog No. A13340
    Quick View
    COX-1 inhibitor
    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. 了解更多
  19. GW-406381

    Catalog No. A19118
    Quick View
    COX-2 inhibitor
    GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. 了解更多
  20. Eicosatetraynoic acid

    Catalog No. A19008
    Quick View
    COX/LOX inhibitor
    Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? 了解更多
  21. Aspirin

    Catalog No. A11797
    Quick View
    COX-1/COX-2 inhibitor
    Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. 了解更多
  22. Naproxen etemesil

    Catalog No. A13052
    Quick View
    COX-1 and COX-2 inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  23. Diclofenac diethylamine

    Catalog No. A16503
    Quick View
    COX inhibitor
    Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. 了解更多
  24. Diclofenac

    Catalog No. A17814
    Quick View
    COX inhibitor
    Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. 了解更多
  25. Etoricoxib D4

    Catalog No. A21877
    Quick View
    COX-2 inhibitor
    Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. 了解更多
  26. Ibuprofen (Advil)

    Catalog No. A10461
    Quick View
    COX-1 抑制剂
    Ibuprofen (Advil)是一种非甾体抗炎药(NSAID),靶向COX-1,IC50为13 μM。 了解更多
  27. Ibuprofen Lysine (NeoProfen)

    Catalog No. A10462
    Quick View
    COX-1 抑制剂
    Ibuprofen Lysine(Motrin)是一种非甾体抗炎药。 了解更多
  28. Asaraldehyde (Asaronaldehyde)

    Catalog No. A10090
    Quick View
    COX-2 抑制剂
    Asaraldehyde (Asaronaldehyde)是一种选择性的COX-2抑制剂。 了解更多
  29. Celecoxib

    Catalog No. A10193
    Quick View
    COX-2 抑制剂
    Celecoxib是一种磺胺类非甾体抗炎药(NSAID)和选择性COX-2抑制剂,在Sf9细胞中IC50为40 nM。 了解更多
  30. Pravadoline (WIN 48098)

    Catalog No. A10749
    Quick View
    COX 抑制剂
    Pravadoline (WIN 48098)是抗炎和前列腺素合成抑制剂,通过抑制环氧合酶(COX)发挥作用。 了解更多
  31. Sulindac (Clinoril)

    Catalog No. A10878
    Quick View
    COX 抑制剂
    Sulindac (Clinoril) 是一种非甾体类COX抑制剂,可有效抑制前列腺素的合成。 了解更多
  32. Flunixin meglumine

    Catalog No. A11686
    Quick View
    COX 抑制剂
    Flunixin Meglumin是一种有效的环氧化酶(COX)抑制剂,用作止痛剂,具有抗炎和解热作用。 了解更多
  33. Acemetacin (Emflex)

    Catalog No. A11692
    Quick View
    COX 抑制剂
    Acemetacin (Emflex)是一种非甾体类抗炎药,是吲哚美辛的乙醇酸酯,是一种环加氧酶抑制剂。 了解更多
  34. Tolfenamic acid

    Catalog No. A11693
    Quick View
    COX-2 抑制剂
    Tolfenamic Acid是一种COX-2抑制剂,IC50为0.2μM。它是非甾体抗炎药(NSAID)的一类。它用于治疗偏头痛的症状。 了解更多
  35. Nimesulide

    Catalog No. A11694
    Quick View
    COX-2 抑制剂
    Nimesulide是一种具有镇痛和解热特性的相对COX-2选择性,非甾体抗炎药(NSAID)。 了解更多
  36. Lornoxicam (Xefo)

    Catalog No. A11695
    Quick View
    COX 抑制剂
    Lornoxicam (Xefo)是一种非甾体类COX-1/COX-2抑制剂。它是oxicam类的非甾体类抗炎药(NSAID),具有镇痛(缓解疼痛),抗炎和退烧(退烧)特性。 了解更多
  37. Licofelone

    Catalog No. A11697
    Quick View
    COX/LOX 抑制剂
    Licofelone是一种COX/LOX双重抑制剂,被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX(环氧合酶)的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。 了解更多
  38. (S)-(+)-Flurbiprofen

    Catalog No. A12434
    Quick View
    COX 抑制剂
    (S)-(+)-Flurbiprofen是一种非选择性的Cox-1和Cox-2抑制剂。 了解更多
  39. Tepoxalin

    Catalog No. A12879
    Quick View
    COX/5-LOX 抑制剂
    Tepoxalin是花生四烯酸代谢的双重环氧合酶/5-脂氧合酶抑制剂,具有有效的抗炎活性和良好的胃肠道功能。 了解更多
  40. Iguratimod (T 614)

    Catalog No. A11464
    Quick View
    COX-2 抑制剂
    Iguratimod (T 614)是一种抗风湿剂,能够有效地抑制COX-2的活性,IC50值为20 μM (7.7 μg/mL),而对 COX-1 无作用;Iguratimod同时为巨噬细胞移动抑制因子 (MIF) 抑制剂,IC50值为6.81 μM。 了解更多
  41. Fexofenadine HCl

    Catalog No. A11859
    Quick View
    COX 抑制剂/histamine H1 receptor 激动剂
    Fexofenadine Hydrochloride是一种抗组胺药,可抑制Cox-1,Cox-2,并且是组胺H1受体激动剂,IC50为246 nM。 了解更多
  42. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 抑制剂
    Radicicol是Hsp90,SRC和Cox-2的有效抑制剂。 了解更多
  43. Piroxicam (Feldene)

    Catalog No. A10736
    Quick View
    COX 抑制剂
    Piroxicam (Feldene)是前列腺素合成的有效抑制剂,并且是Cox-1和Cox-2抑制剂。 了解更多
  44. Phenylbutazone (Butazolidin, Butatron)

    Catalog No. A10720
    Quick View
    COX 抑制剂
    Phenylbutazone (Butazolidin,Butatron)是一种具有研究意义的化合物,它是一种抗炎和抗增殖剂。 了解更多
  45. Indomethacin (Indocid, Indocin)

    Catalog No. A10474
    Quick View
    COX 抑制剂
    Indomethacin (Indocid, Indocin)是一种非选择性COX1和COX2抑制剂,IC50分别为0.1 μg/mL和5 μg/mL。吲哚美辛(吲哚满,吲哚满)是一种非甾体抗炎药,通常用于减轻发热、疼痛、僵硬和肿胀。 了解更多
  46. Diclofenac sodium

    Catalog No. A10304
    Quick View
    COX 抑制剂
    Diclofenac Sodium是一种非选择性的COX抑制剂,完整细胞中的COX-1和-2的IC50分别为0.5μg/ml和0.5μg/ml,作用于绵羊COX-1和COX-2, IC50分别为60和220 nM,用作非甾体类抗炎药(NSAID)来减轻疼痛和减轻疼痛 肿胀发炎。 了解更多
  47. ATB-337

    Catalog No. A11986
    Quick View
    ATB-337是H2S供体和NSAID双氯芬酸的杂合分子。 了解更多
  48. Rofecoxib (Vioxx)

    Catalog No. A11918
    Quick View
    COX-2 抑制剂
    Rofecoxib (Vioxx)是一种COX-2抑制剂,IC50值为18 nM。 了解更多
  49. Phenacetin

    Catalog No. A11906
    Quick View
    Phenacetin是一种非阿片类镇痛药,无抗炎特性。 了解更多
  50. Jaceosidin

    Catalog No. A12080
    Quick View
    Jaceosidin是一种来源于艾蒿的药理活性黄酮,通过阻断培养的人乳腺上皮细胞中erk-1和-2的磷酸化来抑制佛波酯诱导的cox-2和MMP-9的上调。 了解更多

产品 1 到 50 共 64个

每页
页面:
  1. 1
  2. 2

设置升序顺序
Rewards