NPS-2143 (SB-262470)

Name: NPS-2143 (SB-262470)
SKU: A11140

目录号: A11140

CaSR 拮抗剂

NPS-2143 (SB-262470) Chemical Structure

CAS NO. 284035-33-2

NPS-2143 (SB-262470)是一种选择性的Ca2+感应受体拮抗剂，显示可阻止HEK293细胞中表达的人Ca2+受体引起的细胞质Ca2+浓度增加，IC50为43 nM。

库存：现货

规格	价格	数量
10 mg	￥ 850.00
50 mg	￥ 3,500.00
100 mg	￥ 5,500.00
200 mg	￥ 9,000.00
10mM * 1mL in DMSO	￥ 1,000.00

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生物活性

NPS-2143 (SB-262470)是一种选择性的Ca2+感应受体拮抗剂，显示可阻止HEK293细胞中表达的人Ca2+受体引起的细胞质Ca2+浓度增加，IC50为43 nM。

靶点信息

Ca(2+) receptor
43 nM

溶解度 *

In vitro (25°C)	DMSO	79 mg/mL (193.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.46 mL	122.28 mL	244.56 mL
0.5 mM	4.89 mL	24.46 mL	48.91 mL
1 mM	2.45 mL	12.23 mL	24.46 mL
5 mM	0.49 mL	2.45 mL	4.89 mL

*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11140
作用机制	Antagonist (拮抗剂)
M. Wt	408.9
Formula	C24H25ClN2O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	284035-33-2
Synonyms	NPS2143, SB262470
SMILES	CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O