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NSC348884是一种核仁磷酸化蛋白，在核糖体的生物发生，细胞增殖，细胞质/核穿梭运输，核酸结合，核糖核酸裂解和中心体复制中显示出多种生物学活性。NSC 348884是推定的核磷蛋白（NPM）抑制剂。NSC 348884抑制NMP低聚物形成，上调p53并诱导凋亡。
靶点信息
| nucleophosmin | ||||
| In vitro | DMSO | 92 mg/mL (144.47 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.7 mL | 78.52 mL | 157.04 mL |
| 0.5 mM | 3.14 mL | 15.7 mL | 31.41 mL |
| 1 mM | 1.57 mL | 7.85 mL | 15.7 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.14 mL |
*The above data is based on the productmolecular weight 636.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13117 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 636.79 |
| Formula | C38H40N10 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 81624-55-7 |
| Synonyms | NSC 348884, NSC-348884 |
| SMILES | CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C |
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