NVP-AEW541

目录号: A11021

IGF-1R 抑制剂

NVP-AEW541

NVP-AEW541 Chemical Structure

CAS NO. 475489-16-8

NVP-AEW541是一种选择性的IGF-1R激酶抑制剂,可抑制IGF-1R的自磷酸化活性(IC50 = 0.086 uM)并阻止IGF-1介导的MCF-7细胞存活和增殖(IC50分别为0.16和1.64 uM)。

库存: 现货

规格 价格 数量
2 mg
¥ 800.00
5 mg
¥ 1,200.00
10 mg
¥ 1,500.00
25 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 1,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

NVP-AEW541是一种选择性的IGF-1R激酶抑制剂,可抑制IGF-1R的自磷酸化活性(IC50 = 0.086 uM)并阻止IGF-1介导的MCF-7细胞存活和增殖(IC50分别为0.16和1.64 uM)。
In vitro (25°C) DMSO 77 mg/mL (175.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.75 mL 113.74 mL 227.48 mL
0.5 mM 4.55 mL 22.75 mL 45.5 mL
1 mM 2.27 mL 11.37 mL 22.75 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11021
作用机制 Inhibitor (抑制剂)
M. Wt 439.6
Formula C27H29N5O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 475489-16-8
Synonyms AEW541
SMILES C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

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