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NVP-BAG956是一种强效、可逆和ATP竞争性PI3-K/PDK1双激酶抑制剂，对VEGFR 1(IC50 = 2.56 μM)的效力大大降低，对其他15种激酶(IC50 > 10 uM)的活性很小或没有活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.39 mL | 116.96 mL | 233.92 mL |
| 0.5 mM | 4.68 mL | 23.39 mL | 46.78 mL |
| 1 mM | 2.34 mL | 11.7 mL | 23.39 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
*The above data is based on the productmolecular weight 427.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11511 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 427.5 |
| Formula | C28H21N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 853910-02-8 |
| Synonyms | NVP-BAG 956 |
| SMILES | CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5 |
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