OSI-027

目录号: A11056

mTOR 抑制剂

OSI-027

OSI-027 Chemical Structure

CAS NO. 936890-98-1

OSI-027是一种有效的,选择性的,可口服生物利用的mTOR激酶抑制剂,可抑制与mTOR的TORC1和TORC2复合物相关的激酶活性。

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,200.00
50 mg
¥ 3,500.00
100 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 1,160.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

OSI-027是一种有效的,选择性的,可口服生物利用的mTOR激酶抑制剂,可抑制与mTOR的TORC1和TORC2复合物相关的激酶活性。
Targets
Target Value
mTORIC50: 4nM
mTORC1IC50: 22nM
mTORC2IC50: 65nM
PI3KγIC50: 0.42μM
DNA-PKIC50: 1.0μM
PI3KαIC50: 1.3μM
C-RafIC50: 1.6μM
YES1IC50: 2.8μM
EphA2IC50: 4.5μM
BTKIC50: 5.0μM
LCKIC50: 9.5μM
ACK1IC50: >10μM
p38αIC50: 10.6μM
KDRIC50: 19.0μM
PI3KβIC50: >30μM
IGF-1RIC50: >30μM
Insulin ReceptorIC50: >30μM
PDK-1IC50: >30μM
PKAIC50: >30μM
EGFR/ErbB1IC50: >30μM
MST1RIC50: >30μM
SrcIC50: >30μM
MEK1IC50: >30μM
FynIC50: >30μM
In vitro (25°C) DMSO 16 mg/mL (39.36 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.61 mL 123.03 mL 246.06 mL
0.5 mM 4.92 mL 24.61 mL 49.21 mL
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11056
作用机制 Inhibitor (抑制剂)
M. Wt 406.4
Formula C21H22N6O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 936890-98-1
Synonyms OSI027
SMILES COC1=CC=CC2=C/C(=C/3\C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)/N=C21

产品标签

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Product Questions

Product Questions

No Questions
Keywords:购买 OSI-027 | OSI-027 供应商 | 订购 OSI-027 | OSI-027 价格 | OSI-027 生产商 | 订单 OSI-027 | OSI-027 代理商 | 购买 936890-98-1| 936890-98-1 供应商 | 订购 936890-98-1 | 936890-98-1 价格 | 936890-98-1 生产商 | 订单 936890-98-1 | 936890-98-1 代理商|buy OSI-027 | OSI-027 Supplier | purchase OSI-027 | OSI-027 cost | OSI-027 manufacturer | order OSI-027 | OSI-027 distributor | buy 936890-98-1| 936890-98-1 Supplier | purchase 936890-98-1 | 936890-98-1 cost | 936890-98-1 manufacturer | order 936890-98-1 | 936890-98-1 distributor
Rewards