PD0325901

目录号: A10256

MEK 抑制剂

PD0325901

PD0325901 Chemical Structure

CAS NO. 391210-10-9

PD0325901是一种选择性的,非ATP竞争性MEK抑制剂,无细胞试验中IC50为0.33 nM,对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右。

库存: 现货

规格 价格 数量
5 mg
¥ 450.00
10 mg
¥ 900.00
25 mg
¥ 1,500.00
100 mg
¥ 3,100.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PD0325901是一种选择性的,非ATP竞争性MEK抑制剂,无细胞试验中IC50为0.33 nM,对ERK1和ERK2磷酸化抑制作用比CI-1040强500倍左右。
靶点信息
MEK (Cell-free assay)
0.33 nM
In vitro (25°C) DMSO 89 mg/mL (184.57 mM)
Water Insoluble
Ethanol 37 mg/mL (76.73 mM)
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.74 mL 103.69 mL 207.38 mL
0.5 mM 4.15 mL 20.74 mL 41.48 mL
1 mM 2.07 mL 10.37 mL 20.74 mL
5 mM 0.41 mL 2.07 mL 4.15 mL

*The above data is based on the productmolecular weight 482.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10256
作用机制 Inhibitor (抑制剂)
M. Wt 482.2
Formula C16H14F3IN2O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 391210-10-9
SMILES C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O

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