Pexidartinib (PLX3397)

目录号: A15520

CSF1/Kit/FLT3 抑制剂

Pexidartinib (PLX3397)

Pexidartinib (PLX3397) Chemical Structure

CAS NO. 1029044-16-3

Pexidartinib (PLX3397)是KIT,CSF1R和FLT3的小分子酪氨酸激酶(RTK)抑制剂,具有潜在的抗肿瘤活性。

库存: 现货

规格 价格 数量
10 mg
¥ 650.00
25 mg
¥ 1,000.00
50 mg
¥ 1,350.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Pexidartinib (PLX3397)是KIT,CSF1R和FLT3的小分子酪氨酸激酶(RTK)抑制剂,具有潜在的抗肿瘤活性。
靶点信息
Kit CSF-1R Flt3
10 nM20 nM160 nM
In vitro (25°C) DMSO 71 mg/mL (169.93 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.93 mL 119.67 mL 239.34 mL
0.5 mM 4.79 mL 23.93 mL 47.87 mL
1 mM 2.39 mL 11.97 mL 23.93 mL
5 mM 0.48 mL 2.39 mL 4.79 mL

*The above data is based on the productmolecular weight 417.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15520
作用机制 Inhibitor (抑制剂)
M. Wt 417.81
Formula C20H15ClF3N5
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1029044-16-3
Synonyms PLX-3397, PLX 3397
SMILES FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

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