PF-04217903

Name: PF-04217903
SKU: A10711

目录号: A10711

c-Met 抑制剂

PF-04217903 Chemical Structure

CAS NO. 956905-27-4

PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，在A549细胞中IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。

库存：现货

规格	价格	数量
5 mg	￥ 500.00
10 mg	￥ 900.00
50 mg	￥ 2,600.00
100 mg	￥ 4,800.00

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生物活性

PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，在A549细胞中IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。

靶点信息

c-Met (A549 cells)
4.8 nM

溶解度 *

In vitro (25°C)	DMSO	5 mg/mL (13.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.85 mL	134.26 mL	268.53 mL
0.5 mM	5.37 mL	26.85 mL	53.71 mL
1 mM	2.69 mL	13.43 mL	26.85 mL
5 mM	0.54 mL	2.69 mL	5.37 mL

*The above data is based on the productmolecular weight 372.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10711
作用机制	Inhibitor (抑制剂)
M. Wt	372.4
Formula	C19H16N8O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	956905-27-4
Synonyms	PF04217903
SMILES	C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1