PF-5274857

目录号: A12775

Smoothened 抑制剂

PF-5274857

PF-5274857 Chemical Structure

CAS NO. 1373615-35-0

PF-5274857是一种新型Smo拮抗剂,它以4.6±1.1 nmol/L的K(i)特异性结合Smo,并以2.7±1.4 nmol/L的IC(50)完全阻断下游基因Gli1的转录活性。在细胞中。

库存: 现货

规格 价格 数量
5 mg
¥ 810.00
10 mg
¥ 1,380.00
25 mg
¥ 2,430.00
50 mg
¥ 4,050.00
10mM * 1mL in DMSO
¥ 2,510.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PF-5274857是一种新型Smo拮抗剂,它以4.6±1.1 nmol/L的K(i)特异性结合Smo,并以2.7±1.4 nmol/L的IC(50)完全阻断下游基因Gli1的转录活性。在细胞中。
靶点信息
Smoothened Smoothened
4.6 nM(Ki)5.8 nM
In vitro (25°C) DMSO 83 mg/mL (189.95 mM)
Water 83 mg/mL (189.95 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.89 mL 114.43 mL 228.85 mL
0.5 mM 4.58 mL 22.89 mL 45.77 mL
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12775
作用机制 Inhibitor (抑制剂)
M. Wt 436.96
Formula C20H25ClN4O3S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1373615-35-0
Synonyms PF5274857, PF 5274857
SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C

产品标签

产品标签

其他人对该产品使用了下列标签:

使用空格分隔标签。使用单引号(')标注词组。

Product Questions

Product Questions

No Questions
Keywords:购买 PF-5274857 | PF-5274857 供应商 | 订购 PF-5274857 | PF-5274857 价格 | PF-5274857 生产商 | 订单 PF-5274857 | PF-5274857 代理商 | 购买 1373615-35-0| 1373615-35-0 供应商 | 订购 1373615-35-0 | 1373615-35-0 价格 | 1373615-35-0 生产商 | 订单 1373615-35-0 | 1373615-35-0 代理商|buy PF-5274857 | PF-5274857 Supplier | purchase PF-5274857 | PF-5274857 cost | PF-5274857 manufacturer | order PF-5274857 | PF-5274857 distributor | buy 1373615-35-0| 1373615-35-0 Supplier | purchase 1373615-35-0 | 1373615-35-0 cost | 1373615-35-0 manufacturer | order 1373615-35-0 | 1373615-35-0 distributor
Rewards