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Pim

Inhibitory Selectivity
Catalog No.Inhibitor Name Pim1Pim2Pim3Other
A10838SGI-1776 free base
***
*
*
FLT3
A11945SMI-4a
**
A14275CX-6258 HCl
***
**
**
A13203AZD1208
****
***
****
A11967TCS PIM-1 4a
**
*
A12896CX-6258
***
**
**
A15368PIM-1 Inhibitor 2
*
A15369TCS PIM-1 1
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Catalog No. Product Name Application Product Information
A15369 SALE

TCS PIM-1 1

Pim-1 Kinase 抑制剂
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).
A15368

PIM-1 Inhibitor 2

PIM-1 抑制剂
PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM).
A15055

CX-6258 hydrochloride hydrate

Pim 抑制剂
CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.
A14420

LGB-321 HCl

Pan-PIM kinase 抑制剂
LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).
A14275

CX-6258 HCl

Pan-PIM kinase 抑制剂
CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.
A13203 SALE

AZD1208

pan-Pim kinase 抑制剂
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
A12896

CX-6258

Pim 抑制剂
CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.
A11967

TCS PIM-1 4a

Pim 抑制剂
TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively).
A11945 SALE

SMI-4a

Pim 抑制剂
SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
A10838 SALE

SGI-1776 (free base)

PIM1 抑制剂
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

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