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PKC 412 (Midostaurin)

PKC 抑制剂

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产品目录号: A12650

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PKC 412 5mg A12650-5
¥ 1,800.00
PKC 412 10mg A12650-10
¥ 3,000.00
PKC 412 25mg A12650-25
¥ 6,000.00
PKC 412 50mg A12650-50
¥ 10,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

PKC 412 (Midostaurin)

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Chemical Information

目录号 A12650
Mechanism of action Inhibitor
分子量 570.64
化学分子式 C35H30N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 120685-11-2
Synonyms CGP 41251, PKC412, PKC-412, CGP41251, CGP-41251
SMILES code C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
化学名称 [9S-(9??,10??,11??,13??)]-N-(2,3,10,11,12,1?3-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1?H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7?]benzodiazonin-11-yl)-N-methylbenzamide

Biological Activity

Description
PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
Targets
Target Value
PKCαIC50: 22nM
PKCγIC50: 24nM
PKCβ1IC50: 30nM
PKCβ2IC50: 31nM
PPKIC50: 38nM
KDRIC50: 86nM
c-SykIC50: 95nM
PKCηIC50: 160nM
PKCδIC50: 330nM
Flk1IC50: 390nM
CDK1/CyclinBIC50: 570nM
PKAIC50: 570nM
c-FGRIC50: 790nM
c-SrcIC50: 800nM
FLT1IC50: 912nM
PLK1IC50: >1.0μM
p38IC50: >1μM
Tie-1IC50: >1μM
c-MetIC50: >1μM
EGFRIC50: 1.1μM
PKCεIC50: 1.25μM
Myosin-lightchainkinaseIC50: 1.9μM
c-LynIC50: 4.30μM
p70S6KIC50: 5.0μM
CSKIC50: 8.0μM
CDK4/CyclinD1IC50: >10μM
JunkinaseIC50: >10μM
Tie-2IC50: >10μM
FGFR1IC50: >10μM
v-AblIC50: >100μM
ERK1IC50: >200μM
CK1IC50: >200μM
CK2IC50: >200μM
PKBIC50: >300μM
PKCζIC50: 465μM

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