PLK

Catalog No.Inhibitor Name PLK1PLK2PLK3Other
A10134BI 2536
****
**
**
PI3Kα,Met,Tie-2
A10135Volasertib
****
A10673Rigosertib
**
A10442GSK461364
***
A12429MLN0905
***
A13245Ro3280
**
A14426SBE 13 HCl
****
*
A13045NMS-P937
***
A10452HMN-214
A11146TAK-960
****
**
*
A11438GW843682X
***
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BI 2536

    Catalog No. A10134
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    PLK 抑制剂
    BI 2536是Plk1的选择性抑制剂,可在低纳摩尔浓度下抑制Plk1酶的活性。 了解更多
  2. BI6727 (Volasertib)

    Catalog No. A10135
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    PLK 抑制剂
    BI6727 (Volasertib)是一种高效且选择性的polo样激酶(PLK)1抑制剂(在一组癌细胞系中,酶IC50 = 0.87 nM,EC50 = 11-37 nM)。 了解更多
  3. GW843682X

    Catalog No. A11438
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    PLK1/PLK3 抑制剂
    GW843682X是polo-like激酶1(PLK1)和polo-like激酶3(PLK3)的选择性抑制剂(IC50值分别为2.2和9.1 nM)。 了解更多
  4. GSK461364

    Catalog No. A10442
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    PLK 抑制剂
    GSK461364 是polo样激酶1 (Plk1)的ATP竞争性抑制剂。 了解更多
  5. HMN-214

    Catalog No. A10452
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    PLK 抑制剂
    HMN-214抑制polo样和细胞周期蛋白依赖性激酶活性,具有强有力的抗微管作用,并在广泛的人类异种移植物中导致深度凋亡和抗肿瘤活性。 了解更多
  6. TAK-960

    Catalog No. A11146
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    PLK1 抑制剂?
    TAK-960是新型的,口服可用的polo样激酶1选择性抑制剂,具有广谱的临床前抗肿瘤活性。 了解更多
  7. ON-01910 (rigosertib)

    Catalog No. A10673
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    PLK 抑制剂
    ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。 了解更多
  8. MLN 0905

    Catalog No. A12429
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    PLK1 抑制剂
    MLN0905是有效的选择性小分子PLK1抑制剂。MLN0905抑制包括DLBCL细胞系在内的多种人类肿瘤细胞的细胞增殖。 了解更多
  9. RO3280

    Catalog No. A13245
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    PLK1 抑制剂
    RO3280是一种有效的,高选择性的Polo样激酶1(PLK1)抑制剂,IC50为3 nM。 了解更多
  10. NMS-1286937

    Catalog No. A13045
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    PLK 抑制剂
    NMS-1286937是一种小分子Polo样激酶1(PLK1)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  11. SBE 13 HCl

    Catalog No. A14426
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    PLK 抑制剂
    SBE 13 HCl是PLK1的选择性抑制剂,对于PLK1,PLK3和PLK2,IC 50值分别为200pM,875nM和66μM。 了解更多
  12. LFM-A13

    Catalog No. A16261
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    BTK 抑制剂
    LFM-A13是有效且选择性的Btk抑制剂,IC50为17.2 uM;也抑制PLK3,IC50为7.2 uM。 了解更多
  13. AAPK-25

    Catalog No. A19085
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    Aurora/PLK dual 抑制剂
    AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. 了解更多
  14. Poloxime

    Catalog No. A12145
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    PLK1 inhibitor
    Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity. 了解更多

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