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PLK

Inhibitory Selectivity
Catalog No.Inhibitor Name PLK1PLK2PLK3Other
A10134BI 2536
****
**
**
PI3Kα,Met,Tie-2
A10135Volasertib
****
A10673Rigosertib
**
A10442GSK461364
***
A12429MLN0905
***
A13245Ro3280
**
A14426SBE 13 HCl
****
*
A13045NMS-P937
***
A10452HMN-214
A11146TAK-960
****
**
*
A11438GW843682X
***
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10134 SALE

BI 2536

PLK 抑制剂
BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations.
A14426 SALE

SBE 13 HCl

PLK 抑制剂
SBE 13 HCl is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively).
A13045

NMS-1286937

PLK 抑制剂
NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.
A13245

RO3280

PLK1 抑制剂
RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
A12429

MLN 0905

PLK1 抑制剂
MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines.
A11438

GW843682X

PLK1/PLK3 抑制剂
GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively).
A10673 SALE

ON-01910 (rigosertib)

PLK 抑制剂
ON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress.
A10135 SALE

BI6727 (Volasertib)

PLK 抑制剂
BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines).
A11146 SALE

TAK-960

PLK1 抑制剂?€?
TAK-960 is a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity.
A10452

HMN-214

PLK 抑制剂
HMN-214 inhibits polo-like and cyclin-dependent kinase activity, has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts.
A10442 SALE

GSK461364

PLK 抑制剂
GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1).
A16261

LFM-A13

BTK 抑制剂
LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM.

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