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Proteases | 蛋白酶



产品 1 到 50 共 241个

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Catalog No. Product Name Application Product Information
A10984 SALE

VX-765 (Belnacasan)

Caspase-1/4 抑制剂
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
A12373 SALE

Z-VAD-FMK

Pan Caspase 抑制剂
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
A14100

Nivocasan (GS-9450)

Caspase 抑制剂
Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
A13503 SALE

Z-DEVD-FMK

Caspase-3 抑制剂
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
A14358

Z-LEHD-FMK

Caspase-9 抑制剂
Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
A14915 SALE

Q-VD-OPh hydrate

Caspase 抑制剂
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
A14916

Z-WEHD-FMK

Caspase 抑制剂
Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.
A14919

Caspase-3/7 Inhibitor I

Caspase-3/7 抑制剂
Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
A15291

Ac-LEHD-AFC

Fluorogenic caspase substrate
Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
A15294

AZ 10417808

Caspase-3 抑制剂
AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
A15300

Ivachtin

Caspase-3 抑制剂
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
A15308

PETCM

Caspase-3 activator
PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
A15319

Ac-IEPD-AFC

Fluorogenic caspase substrate
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
A15816

Ac-DEVD-CHO

Caspase 抑制剂
Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.
A12611

Z-VEID-FMK

Caspase-6 抑制剂
Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2.
A12637

Z-VDVAD-FMK

Caspase-2 抑制剂
Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
A12697

Z-DQMD-FMK

Caspase-3 抑制剂
Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
A12800

Z-IETD-FMK

caspase 8 抑制剂
Z-IETD-FMK is a specific inhibitor of caspase 8.
A11090 SALE

PAC-1

Caspase activator
PAC-1 is first procaspase activating compound.
A11944

Apoptosis Activator 2

Apoptosis Activator
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
A13070 SALE

LY573636 (Tasisulam)

Apoptosis inducer
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
A14284

Z-FA-FMK

Irreversible Cysteine Protease 抑制剂
Z-FA-FMK is an irreversible cysteine protease inhibitor.
A13704

25-hydroxy Cholesterol

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25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types
A15392

Boc-D-FMK

Caspase 抑制剂
BOC-D-FMK is a Novel inhibitor of Caspase-3.
A16317

Z-YVAD-FMK

Caspase-1 抑制剂
Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
A16340

Z-VAD(OH)-FMK

Caspase 抑制剂
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
A16381

Z-FA-FMK

Cysteine protease 抑制剂
Z-FA-FMK is an irreversible inhibitor of cysteine protease
A15090

gamma-secretase modulator 3

gamma-secretase modulator
gamma-secretase modulator 3 is a gamma-secretase modulator.
A15296

Compound W

Gamma-secretase modulator
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
A15301

JLK 6

??-secretase 抑制剂
JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
A15304

MRK 560

??-secretase 抑制剂
MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
A11259

PF-03084014

??-secretase 抑制剂
PF-03084014 is a reversible and selective inhibitor of ??-secretase with IC50 value of 6.2 nM .
A13662

Flurbiprofen Axetil

gamma-secretase 抑制剂
Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
A15899

L-685458

??-secretase 抑制剂
L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
A13319

PF-03084014

??-secretase 抑制剂
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2.
A11258

Begacestat (GSI-953)

??-secretase 抑制剂
Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
A11425

gamma-secretase modulator 1

Gamma-secretase modulator
gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
A11427

gamma-secretase modulator 2

Gamma-secretase modulator
gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
A13217

TC-E 5006

Gamma-secretase modulator
TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
A16214

CHF5074

??-Secretase modulator
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.
A16215

Z-Ile-Leu-aldehyde

??-Secretase 抑制剂
Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
A10802 SALE

RO4929097

Gamma-secretase 抑制剂
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
A10157

BMS-708163 (Avagacestat)

Gamma-secretase 抑制剂
BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
A11194 SALE

MK-0752

Gamma-secretase 抑制剂
MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
A10288 SALE

DAPT (GSI-IX)

Gamma secretase 抑制剂
DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
A11174 SALE

YO-01027

??-secretase 抑制剂
YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
A11176 SALE

LY-411575

Gamma secretase 抑制剂

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

A10836 SALE

Semagacestat (LY450139)

Gamma-secretase 抑制剂
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
A11776 SALE

LY2811376

BACE1 抑制剂
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
A11337

BMS 433796

??-Secretase 抑制剂
BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.

产品 1 到 50 共 241个

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