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R112是Syk抑制剂。R112抑制了肥大细胞中抗IgE交联诱导的脱颗粒，并阻断了白三烯C4的产生和所有促炎细胞因子的测试。
| In vitro | DMSO | 61 mg/mL (195.32 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.02 mL | 160.1 mL | 320.2 mL |
| 0.5 mM | 6.4 mL | 32.02 mL | 64.04 mL |
| 1 mM | 3.2 mL | 16.01 mL | 32.02 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
*The above data is based on the productmolecular weight 312.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14161 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 312.3 |
| Formula | C16H13FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 575474-82-7 |
| Synonyms | R 112, R-112 |
| SMILES | C1=CC(=CC(=C1)O)NC2=NC(=NC=C2F)NC3=CC(=CC=C3)O |
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