Raf

Catalog No.Inhibitor Name RafC-Raf/Raf-1B-RafA-rafOther
A10739Vemurafenib
*
**
SRMS,ACK1,MAP4K5 (KHS1)
A10002PLX-4720
***
***
BRK,FRK,CSK
A11381Dabrafenib
****
****
A10420GDC-0879
****
A10773RAF265
**
VEGFR2
A11063AZ 628
**
**
A10661NVP-BHG712
*
EphB4,c-Src,c-Abl
A10829SB590885
****
A11077ZM 336372
*
A10001Sorafenib
****
**
mVEGFR2(Flk1),mVEGFR3,mPDGFRβ
A11436GW5074
***
A13323TAK-632
****
***
Aurora B,PDGFRβ,FGFR3
A13772CEP-32496
**
***
RET,PDGFRβ,LCK
A13226Encorafenib
****
A14019RO5126766
*
***
MEK1
A15855PLX7904
A11240MLN2480
A10250Regorafenib (BAY 73-4506)
****
**
FGFR1, Kit, PDGFRβ, RET, Tie-2 , VEGFR1, VEGFR2, VEGFR3
A11211ML 786 dihydrochloride
****
****
Abl-1, DDR2, EPHA2, RET, PERK
A12739PF-04880594
****
****
A13525L-779450
****
p38α, GSK3β, Lck

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. TAK-632

    Catalog No. A13323
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    pan-RAF 抑制剂
    TAK-632是一种有效的泛RAF抑制剂,具有良好的体外活性(BRAF(V600E)IC50,2.4 nM; BRAF(wt),8.3 nM; CRAF,1.4 nM; pMEK(A375)IC50,12 nM; pMEK(HMVII ),49 nM。 了解更多
  2. RO5126766 (CH5126766)

    Catalog No. A14019
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    Raf/MEK dual 抑制剂
    RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶(MAPK)具有特异性的蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  3. B-Raf-inhibitor 1

    Catalog No. A14122
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    B-Raf 抑制剂
    B-Raf inhibitor 1是有效的选择性B-Raf抑制剂,对A375增殖和A375 p-ERK的细胞IC50分别为0.31 uM和2 nM。 了解更多
  4. CEP-32496 hydrochloride

    Catalog No. A15040
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    Raf 抑制剂
    CEP-32496 hydrochloride是野生型BRAF,V600E突变型BRAF和c-Raf的高效抑制剂,Kd值分别为14 nM,36 nM和39 nM。 了解更多
  5. Dabrafenib Mesylate

    Catalog No. A15059
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    Raf 抑制剂
    Dabrafenib Mesylate是一种新颖,有效和选择性的Raf激酶抑制剂,能够抑制野生型B-Raf,B-RafV600E和c-Raf的激酶活性,IC50值分别为3.2、0.8和5.0 nM。 了解更多
  6. PLX7904

    Catalog No. A15855
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    Raf 抑制剂
    PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活,但不能过度激活突变型RAS表达细胞中的ERK1/2。 了解更多
  7. ML 786 dihydrochloride

    Catalog No. A11211
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    Raf 抑制剂
    ML 786 dihydrochloride是一种有效的Raf激酶抑制剂(B-RafV600E,C-Raf和野生型B-Raf的IC50值分别为2.1、2.5和4.2 nM)。 了解更多
  8. HG6-64-1

    Catalog No. A16022
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    B-Raf 抑制剂
    HG6-64-1是有效的选择性B-Raf和突变B-Raf抑制剂;更多信息可以在专利WO 2011090738中找到。 了解更多
  9. LUT014

    Catalog No. A19449
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    B-Raf inhibitor
    LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 . 了解更多
  10. ERK-IN-1

    Catalog No. A19080
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    RAF/ERK1/2 inhibitor
    ERK-IN-1 (compound B) is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. 了解更多
  11. RAF mutant-IN-1

    Catalog No. A19011
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    Raf nhibitor
    RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF340D/Y341D, B-RAFV600E and B-RAFWT, respectively. 了解更多
  12. Belvarafenib

    Catalog No. A13177
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    pan RAF inhibitor
    Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. 了解更多
  13. Regorafenib Hydrochloride

    Catalog No. A11546
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    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. 了解更多
  14. LY3009120

    Catalog No. A16603
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    pan RAF inhibitor
    LY3009120 is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively. 了解更多
  15. B-Raf IN 1

    Catalog No. A21055
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    B-Raf kinase inhibitor
    B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. 了解更多
  16. B-Raf inhibitor 1 dihydrochloride

    Catalog No. A21834
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    Raf kinase inhibitor
    B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. 了解更多
  17. Lifirafenib

    Catalog No. A20988
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    Raf/EGFR inhibitor
    Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. 了解更多
  18. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR 抑制剂
    Regorafenib (BAY 73-4506)是一种多激酶抑制剂,IC50为17、40和69 nM c-KIT,VEGFR2,B-Raf。Regorafenib(BAY 73-4506)是一种针对肿瘤及其脉管系统的口服生物利用型多激酶抑制剂。 了解更多
  19. Sorafenib Tosylate (Nexavar)

    Catalog No. A10001
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    Raf 抑制剂
    Sorafenib Tosylate (Nexavar)是几种酪氨酸蛋白激酶(VEGFR和PDGFR)和RAF/MEK/ERK级联抑制剂的新型小分子抑制剂,Raf-1,wt BRAF和V599E突变型BRAF的IC50为6、22、38 nM。 了解更多
  20. PLX4032 (Vemurafenib)

    Catalog No. A10739
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    Raf 抑制剂
    PLX4032(Vemurafenib)也称为RG7204,Vemurafenib,R7204,RO5185426。PLX4032是B-raf抑制剂,IC50为44 nM。 了解更多
  21. NVP-BHG712

    Catalog No. A10661
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    EphB4 抑制剂
    NVP-BHG712是EphB4激酶的选择性抑制剂,在体外对EphB4的选择性超过40多种其他激酶(包括FGFR3)。 了解更多
  22. Dabrafenib (GSK2118436A)

    Catalog No. A11381
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    Raf 抑制剂
    Dabrafenib (GSK2118436A)是一种有效且选择性的B-RAF蛋白激酶抑制剂,具有V600E突变,目前正在临床试验中。 了解更多
  23. Balamapimod (MKI-833)

    Catalog No. A13119
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    Ras/Raf/MEK 抑制剂
    Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。 了解更多
  24. LGX 818 (Encorafenib)

    Catalog No. A13226
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    Selective B-RAF 抑制剂
    LGX 818 (Encorafenib)是一种Raf激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  25. PLX-4720

    Catalog No. A10002
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    Raf 抑制剂
    PLX-4720是一种有效的,选择性的B-RafV600E抑制剂,无细胞试验中IC50为13 nM,同样有效地作用于c-Raf-1(Y340D和Y341D突变型),作用于B-RafV600E比作用于野生型B-Raf选择性高10倍。 了解更多
  26. L-779450

    Catalog No. A13525
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    Raf 抑制剂
    L-779450是有效的选择性 B-Raf 抑制剂,Kd 为 2.4 nM。是神经外伤性疾病的潜在治疗方法。 了解更多
  27. RAF265 (CHIR-265)

    Catalog No. A10773
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    RAF/VEGFR 抑制剂
    RAF265 (CHIR-265)是一种口服,高度选择性的RAF和VEGFR激酶抑制剂,可控制或正常化VEGFR-2,同时抑制B-raf和c-Raf突变以预防癌症。 了解更多
  28. GDC-0879

    Catalog No. A10420
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    B-Raf 抑制剂
    GDC-0879是B-Raf激酶的特异性抑制剂,靶向B-Raf (V600E) (IC50: 0.13 nM)。 了解更多
  29. AZ628

    Catalog No. A11063
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    Raf 抑制剂
    AZ628是一种RAF抑制剂,IC50值:BRAF V600E和野生型CRAF约为30 nM,野生型BRAF约为100 nM。 了解更多
  30. SB590885

    Catalog No. A10829
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    B-Raf 抑制剂
    SB590885是B-Raf激酶的选择性小分子抑制剂,B-Raf和c-Raf的Ki app值分别为0.16和1.72 nM。 了解更多
  31. ZM 336372

    Catalog No. A11077
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    C-Raf 抑制剂
    ZM 336372是有效的ATP Raf-1体外竞争性抑制剂 (IC50 = 70 nM)。 了解更多
    • 最新产品

    AZ304

    Catalog No. A17225
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    dual BRAF 抑制剂
    AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. 了解更多
  32. Lifirafenib (BGB-283)

    Catalog No. A16844
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    BRAF 抑制剂
    Lifirafenib (BGB-283),也称为Beigene-283,在生化分析中有效抑制RAF家族激酶和EGFR活性,重组BRAFV600E激酶结构域,EGFR和EGFR T790M/L858R突变体的IC50值为23、29和495 nM。 了解更多
  33. RAF709

    Catalog No. A16842
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    raf kinase 抑制剂
    RAF709是B/C RAF激酶的有效抑制剂,对B-RAF和C-RAF的IC50值几乎相等,为0.4 nM。它具有高选择性,在浓度为1 μM时,对BRAF, BRAFV600E和CRAF的靶向结合率大于99%,而对DDR1、DDR2、FRK和FDGFRβ的脱靶效应非常少。 了解更多
  34. LXH254

    Catalog No. A16841
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    pan-RAF 抑制剂
    LXH254是II型ATP竞争性抑制剂,可在皮摩尔浓度下抑制B/C RAF激酶活性,对456种人类激酶和基于细胞的测定具有高度选择性。 了解更多
  35. Locostatin

    Catalog No. A16079
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    RKIP/Raf1 抑制剂
    Locostatin是Raf激酶抑制剂蛋白(RKIP/Raf1激酶相互作用的细胞渗透性强抑制剂,是细胞迁移的抑制剂。 了解更多
  36. Diazepinomicin

    Catalog No. A12891
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    RAS/RAF/MAPK 抑制剂
    Diazepinomicin,也称为TLN-4601,是具有潜在抗肿瘤活性的RAS/RAF/MAPK信号传导途径的小分子抑制剂。 了解更多
  37. Raf265 derivative

    Catalog No. A10774
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    RAF/VEGFR 抑制剂
    Raf265 derivative是Raf265的衍生物,Raf265是一种口服,高度选择性的RAF和VEGFR激酶抑制剂,IC50为5至10μM。 了解更多
  38. BRAF inhibitor

    Catalog No. A11333
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    BRAF 抑制剂
    BRAF inhibitor是一种有效的BRAF抑制剂。 了解更多
  39. Regorafenib monohydrate

    Catalog No. A15218
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    Tyrosine kinase 抑制剂
    Regorafenib monohydrate是VEGFR1/VEGFR2/VEGFR3/PDGFRβ/Kit/RET和Raf-1的多靶点抑制剂,IC50分别为13 nM/4.2 nM/46 nM/22 nM/7 nM/1.5 nM和2.5 nM。 了解更多
  40. GW 5074

    Catalog No. A11436
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    Raf-1 抑制剂
    GW 5074是一种强效、选择性和细胞渗透性的c-Raf1激酶抑制剂。 了解更多
  41. MLN2480 (BIIB-024)

    Catalog No. A11240
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    pan-Raf 抑制剂
    MLN2480 (BIIB-024)是一种口服的Raf激酶抑制剂。 了解更多
  42. CEP-32496

    Catalog No. A13772
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    Raf 抑制剂
    CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1(B-raf)丝氨酸/苏氨酸蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  43. PF-04880594

    Catalog No. A12739
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    RAF 抑制剂
    PF-04880594是RAF抑制剂,BRAF/BRAFV599E和c-RAF的IC50值分别为0.19 nM/0.13 nM和0.39 nM。 了解更多

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